Doxycycline-Teva 100 mg 2p x 10 tablets — Made in Germany — Free Delivery

- hypersensitivity to doxycycline, to any auxiliary substance of the drug or to other tetracyclines;

severe liver dysfunction;

During pregnancy and breastfeeding;

patients with allergic reactions to soy or peanuts should not use this medication.

In patients receiving tetracycline, including doxycycline, the following adverse reactions were noted.

Infections and invasions: superinfection, which can cause candidiasis, glossitis, stomatitis, enterocolitis, pseudomembranous colitis (with increased growth of Clostridium difficile), acute inflammation of the vulva and vagina in women (vulvovaginitis), proctitis, itching in the anal area (anal itching) ...

From the hematopoietic and lymphatic system: blood coagulation disorders, decreased prothrombin activity, hemolytic anemia, leukopenia, leukocytosis, thrombocytopenia, anemia, lymphocytopenia, lymphadenopathy, the presence of atypical lymphocytes and toxic granulocyte granulocytes, neutropenia, eosinophilia.

Immune system disorders: photosensitization, hypersensitivity reactions (including anaphylactic shock, anaphylaxis, angioedema, dyspnoea, serum sickness, peripheral edema, tachycardia, urticaria), anaphylactoid reactions, anaphylactoid purpura, pseudo-anaphylactic reaction polymorphic exudative erythema, reversible local edema of the skin, mucous membrane or joints (angioedema), asthma, local exanthema of the genitals and other zones, malignant exudative erythema, facial edema, tongue edema, laryngeal edema with narrowing of the airways, tachycardia, arterial hypotension, which can progress to shock, severe skin reactions with general reactions (such as exfoliative dermatitis and Lyell's syndrome), pericarditis, exacerbation of systemic lupus erythematosus. Allergic reactions to soy proteins can occur.

Mental disorders: fear, anxiety, agitation, convulsions (reported a case of epileptic seizure after oral administration of doxycycline).

From the nervous system: headache, paresthesias, malignant intracranial hypertension (Pseudotumor cerebri), disappearing after stopping treatment and characterized by headache, nausea, vomiting, possible visual impairment (blurred vision, scotoma, diplopia, temporary loss of vision) due to edema of the optic nerve , hot flashes, reversible partial loss of olfactory and gustatory sensitivity, prolonged loss of vision. Bulging fontanelle in neonates and benign intracranial hypertension in children and adults have been reported with tetracyclines at full therapeutic doses.

On the part of the organ of hearing and vestibular apparatus: ringing in the ears, tinnitus, vertigo.

On the part of the cardiovascular system: tachycardia.

From the digestive tract: nausea, diarrhea, dyspepsia, heartburn, abdominal pain, discoloration of tooth enamel, vomiting, dysphagia, esophagitis, pancreatitis, villous tongue, blackening of the tongue, enamel hypoplasia, bloating, flatulence, steatorrhea, stomatitis, stomatitis dysphonia, difficulty swallowing, pseudomembranous enterocolitis, anorexia, irreversible discoloration of teeth and damage to enamel. If the doxycycline monohydrate tablet is improperly swallowed (for example, in the supine position), ulcers of the esophagus can occur, since the tablets adhere to the esophageal mucosa and powerful acids can be released locally by hydrolysis. Common symptoms of esophagitis and esophageal ulcers include odonophagia, chest pain, and dysphagia.

From the hepatobiliary system: hepatitis, jaundice, hepatic failure, hepatotoxicity with a temporary increase in liver function values.

On the part of the skin and subcutaneous tissue: exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, rash, including maculopapular and erythematous rashes, photosensitivity of the skin (redness, edema, blistering and skin discoloration), photoonycholysis can cause an allergic reaction nails (peeling and discoloration of nails), drug hypersensitivity syndrome with eosinophilia and systemic symptoms (DRESS).

Musculoskeletal and connective tissue disorders: myalgia, arthralgia.

From the kidneys and urinary tract: hematuria, interstitial nephritis, acute renal failure, anuria, increased blood urea levels. Metabolized tetracyclines caused a syndrome similar to Fanconi's syndrome, including albuminuria, aminoaciduria, hypophosphatemia, hypokalemia, and renal tubular acidosis.

Tetracyclines can cause nephrotoxicity or worsen previous kidney damage (characterized by elevated plasma creatinine and urea levels).

Other disorders: when using tetracyclines for a long time, microscopic staining of thyroid tissue in a brown-black color was noted. At the same time, no pathology of the thyroid gland was revealed.