Essliver Forte 50 capsules — Made in India — Free Delivery

Pharmacological properties

The main active ingredient of the preparation is natural phospholipids (substance epl). phospholipids in their chemical structure are similar to endogenous phospholipids, but surpass them due to the high content of polyunsaturated fatty acids. these molecules are incorporated mainly into the structures of cell membranes and facilitate the restoration of damaged liver tissue. phospholipids have a hepatoprotective effect on damage to liver cells by viruses, alcohol, toxic substances. in cells, the rate of intake and excretion of substances increases, the restoration of enzyme systems and an improvement in liver metabolism are ensured.

Phospholipids affect disturbed fat metabolism by regulating lipoprotein metabolism, as a result of which neutral fats and cholesterol are converted into forms suitable for transport, especially due to an increase in the ability of HDL to attach cholesterol, and are sent for further oxidation. With the excretion of phospholipids through the biliary tract, the lithogenic index decreases and bile stabilizes.

The vitamin complex performs the following functions: nicotinamide has a lipid-lowering effect and prevents fatty degeneration of the liver; pyridoxine as a coenzyme takes part in the metabolism of phospholipids, amino acids and proteins; thiamine is involved in carbohydrate metabolism; riboflavin is a cofactor for numerous respiratory enzymes; tocopherol acts as an antioxidant at the level of the cell membrane, prevents the oxidation of unsaturated fatty acids.

When taken orally, more than 90% of the preparation is absorbed in the small intestine. The main amount is cleaved by phospholipase-A to 1-acyl-lyso-phosphatidylcholine, 50% of which is immediately split into polyunsaturated phosphatidylcholine even during absorption in the small intestine. Polyunsaturated phosphatidylcholine enters the bloodstream through the lymphatic pathways and then, mainly in combination with HDL, is transported to the liver. The maximum content of phosphatidylcholine in the blood 6-24 hours after oral administration averages 20%.

Indications

Fatty liver degeneration (including liver damage in diabetes), acute and chronic hepatitis, liver cirrhosis, pre- and postoperative treatment of the patient with surgery on the liver and biliary tract, toxic liver damage, pregnancy toxicosis, psoriasis, radiation syndrome.

Application

The dose for adults and children over the age of 12 is usually 1-2 capsules 3 times a day. take the capsules with food, without chewing, with a little water.

Doses of the preparation and the duration of treatment are determined by the doctor individually for each patient, taking into account the nature and severity of the pathological process, the characteristics of the course of the disease, the achieved therapeutic effect and the tolerability of the preparation. On average, the course of treatment is at least 3 months.

Treatment of psoriasis begins with the appointment of the preparation, 2 capsules 3 times a day for 2 weeks, and then in combination with conventional methods of treating psoriasis, 1 capsule 3 times a day for 2 months.

Contraindications

Hypersensitivity to the components of the preparation. allergic diseases. intrahepatic cholestasis. ulcers of the stomach and duodenum in the acute stage.

Side effects

In some cases, when using the preparation, the following side effects may occur.

From the digestive tract: dyspeptic disorders, nausea, vomiting, diarrhea, constipation, heartburn, discomfort and pain in the epigastrium.

On the part of the skin and subcutaneous tissue: skin rash, urticaria, itching.

In persons with individual intolerance to any component of the preparation, hypersensitivity reactions are possible, including angioedema, anaphylaxis.

The urine may turn yellow.

Special instructions

With caution and after consulting a doctor, use the preparation for severe heart disease, kidney disease, an increased risk of thromboembolism, patients with a history of stomach and duodenal ulcers, neoplasms, nephrolithiasis, erythremia, erythrocytosis, hyperuricemia.

The use of the preparation can lead to a false positive test for urobilinogen using the Ehrlich reagent.

Use during pregnancy and lactation. The preparation can be used during pregnancy and lactation according to indications for the purpose and under the supervision of a physician.

Children. It is used to treat children over the age of 12 years.

The ability to influence the reaction rate when driving or working with other mechanisms. Does not affect.

Interactions

Vitamin B6 weakens the effect of levodopa, prevents or reduces toxic manifestations that develop with the use of isoniazid and other anti-tuberculosis preparations.

PASK, cimetidine, calcium preparations, ethanol reduce the absorption of vitamin B12.

Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial preparations (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). The tricyclic antidepressants, imipramine and amitriptyline, inhibit the metabolism of riboflavin, especially in the heart tissues.

It is not recommended to prescribe concurrently with other multivitamin preparations, since the latter may be overdose in the body.

Vitamin E should not be used simultaneously with iron and silver preparations, agents with an alkaline medium (sodium bicarbonate, trisamine), indirect anticoagulants (dicumarin, neodikumarin).

Vitamin E enhances the effect of steroidal and non-steroidal anti-inflammatory preparations (sodium diclofenac, ibuprofen, prednisolone), reduces the toxic effect of cardiac glycosides (digitoxin, digoxin), vitamins A and D. The administration of vitamin E in high doses can cause vitamin A deficiency in the body.

Vitamin E and its metabolites exhibit an antagonistic effect relative to vitamin K. Increases the effectiveness of antiepileptic preparations in patients with epilepsy (in whom the content of LPO products in the blood is increased).

Cholestyramine, colestipol, mineral oils reduce the absorption of vitamin E.

Overdose

Symptoms: nausea, vomiting, diarrhea, headache, drowsiness, lethargy, facial flushing, irritability, increased manifestations of adverse reactions. with prolonged use in high doses, peripheral neuropathy is possible.

Treatment: gastric lavage, the appointment of activated carbon, hyperosmotic laxatives.

Storage conditions

At a temperature not higher than 25 ° C.