Ethacizine 50mg 50 tablets — Made in Latvia — Free Delivery

(Ethacizin 50mg)
Ethacizine 50mg 50 tablets — Made in Latvia — Free Delivery
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Olainfarm Brand: Olainfarm

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Description Ethacizine 50mg 50 tablets — Made in Latvia — Free Delivery

Pharmacological properties

Pharmacodynamics. Ethacizine (ethacyzine) is a class ic antiarrhythmic preparation, has a pronounced and long-term antiarrhythmic effect. Oppresses the rate of growth of the action potential front, does not change the rest potential. Affects mainly sodium channels (both on the outer and inner surfaces of the cell membrane), reduces the amplitude and slows down the processes of inactivation and reactivation of the fast sodium flow. Blocks the entry of calcium ions through the slow channels of the membrane. Extends the duration of the refractory periods of the atria and av-node. It slows down the rate of increase in the action potential in the atrial and ventricular fibers of Purkinje and additional pathways for conducting excitation along the av-node and kenta bundle. Suppresses sinoatrial conduction, especially in sick sinus syndrome, expands the qrs complex on the ecg (by about 25%), since it slows down the conduction of the ventricles (in the purkinje system). Has a negative inotropic effect, shows local anesthetic and antispasmodic activity. etacizin does not change the heart rate with short-term use and decreases with long-term use.

Pharmacokinetics. When taken orally Etatsizin is rapidly absorbed in the digestive tract and is determined in the blood after 30-60 minutes. Cmax of Etacizin in blood plasma is recorded after 2.5–3 hours. Bioavailability is 40%. 90% binds to blood plasma proteins. T½ averages 2.5 hours. All of the listed pharmacokinetic parameters are subject to significant individual fluctuations. Etacizin is extensively metabolized during the initial passage through the liver. Some of the resulting metabolites have antiarrhythmic activity. It is excreted from the body in the urine in the form of metabolites.

Indications

Ventricular and supraventricular extrasystole, paroxysms of atrial fibrillation and atrial flutter, ventricular and supraventricular tachycardia, including with the syndrome of premature excitation of the ventricles.

Application

Inside, regardless of food intake, starting with 50 mg 2-3 times a day. in case of insufficient clinical effect, the dose is increased (under mandatory ECG control) to 50 mg 4 times a day (200 mg) or 100 mg 3 times a day (300 mg).

When a stable antiarrhythmic effect is achieved, maintenance therapy is carried out in individually selected minimum effective doses. Some patients require combined treatment with Etacizin and β-adrenergic receptor blockers to achieve a stable antiarrhythmic effect.

Contraindications

Hypersensitivity to the preparation or excipients; severe conduction disorders (including sinoatrial blockade, av-block II – III degree in the absence of an artificial pacemaker), impaired intraventricular conduction; severe hypertrophy of the left ventricular myocardium; the presence of postinfarction cardiosclerosis; cardiogenic shock; acute coronary syndrome; acute myocardial infarction and a period of 3 months after acute myocardial infarction; pronounced expansion of the heart cavity; decrease in the ejection fraction of the left ventricle (echocardiography data), arrest of the sinus node; severe arterial hypotension; chronic heart failure III and IV class; severe liver and / or kidney dysfunction; electrolyte imbalance (hypokalemia, hyperkalemia, hypomagnesemia); concomitant use of MAO inhibitors; simultaneous use of antiarrhythmic preparations ic (moracizin (etmozin), propafenone, allapinin) and class ia (quinidine, procainamide, disopyramide, aymalin); cardiac arrhythmias in combination with blockages of conduction through the bundle of his system - Purkinje fibers.

Side effects

They depend on the size of the dose, and in order to avoid the occurrence of side effects, the maximum dose of the preparation should not be prescribed.

Individuals with individual intolerance may experience allergic reactions.

From the side of the cardiovascular system: stopping the sinus node, AV blockade, impaired intraventricular conduction, decreased myocardial contractility, decreased coronary blood flow, arrhythmia. Arrhythmogenic effect, the likelihood of which is highest after myocardial infarction and in other types of cardiac pathology, which leads to a decrease in myocardial contractile function and the development of heart failure, a proarrhythmogenic effect with a risk of sudden death.

ECG changes: lengthening of the P – Q interval, expansion of the P wave and QRS complex.

From the side of the central nervous system: dizziness, headache, staggering when walking or turning the head, slight drowsiness; in some cases, marked diplopia, paresis of accommodation.

From the gastrointestinal tract: nausea, pain in the epigastric region.

It is possible to reduce or disappear side effects after using the preparation for 3-4 days. With long-term treatment with Etacizin, side reactions do not increase, and with discontinuation of the preparation, they quickly disappear.

special instructions

In case of myocardial infarction, the preparation can be prescribed subject to strict medical supervision

It is advisable to start treatment 3 months after the development of myocardial infarction.

With extreme caution, it is prescribed for sick sinus syndrome, bradycardia, degree I AV block, coronary artery disease, severe peripheral circulatory disorders, functional class I chronic heart failure, angle-closure glaucoma, benign prostatic hypertrophy, cardiomegaly (the risk of arrhythmogenic effects increases), patients with pacemakers (increased risk of arrhythmias), hepatic / renal failure.

Like other antiarrhythmic preparations, Etacizin can act arrhythmogenic. Therefore, when prescribing Etatsizin, it is necessary:

1. Strictly take into account the contraindications to the use of the preparation.

2. Pre-identify and eliminate hypokalemia.

3. Prevent the use of Etacizin simultaneously with class IA and IC antiarrhythmic preparations.

4. It is advisable to start the course treatment in a hospital (especially during the first 3-5 days of using the preparation and taking into account the dynamics of the ECG after the trial and repeated doses of Etacizin or ECG monitoring data).

5. Immediately stop course treatment in case of increased frequency of ectopic ventricular complexes, manifestations of blockages or bradycardia. Treatment with Etacizin should also be discontinued immediately when the ventricular complexes expand by more than 25%, their amplitude decreases, when the P wave expands on an ECG of 0.12 s or Q-T intervals of 500 ms. The preparation should be used with caution if the Q – T interval is 400 ms.

Risk factors for the arrhythmogenic action of Etatsizin are: organic heart damage (especially suffered myocardial infarction), a decrease in the left ventricular ejection fraction.

The arrhythmogenic effect of the preparation is not directly dose dependent. To reduce it, the simultaneous use of Etacizin and β-adrenergic receptor blockers in low doses is recommended.

During treatment, it is necessary to regularly monitor the patient's condition and the function of the cardiovascular system (ECG, blood pressure, echocardiography).

The preparation should not be used in patients with rare congenital fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase deficiency.

The tablet shell contains sunset yellow dye (E110), which can cause allergic reactions.

Patients with sinus syndrome, especially at the first use of the preparation, need an ECG control 2-3 days after the start of the preparation intake.

Patients with impaired liver function during long-term treatment should be careful, since a hepatotoxic effect is possible (in severe liver impairment, use is contraindicated).

When treating with Etacizin, alcohol should not be consumed.

Application during pregnancy or lactation. During pregnancy or lactation, the use of the preparation is contraindicated.

Children. The use of the preparation in children is contraindicated.

The ability to influence the reaction rate when driving or working with other mechanisms. During treatment with the preparation, one should refrain from driving and working with potentially dangerous mechanisms.

Interactions

The simultaneous use of class ic antiarrhythmic preparations - moracizin, encainide, flecainide, propafenone - is contraindicated. the combination of β-adrenergic receptor blockers with class ic antiarrhythmic preparations (etacizin) enhances the antiarrhythmic effect, especially in relation to arrhythmias that are provoked by physical exertion or stress. this combination allows the use of an antiarrhythmic preparation in low doses, which reduces the frequency of its side effects. this combination is indicated for the treatment and prevention of paroxysmal tachycardias, including ventricular tachycardias.

Etacizin can be combined with amiodarone (class III). In such cases, the dose of both preparations should be reduced. To prevent ventricular fibrillation or ventricular paroxysmal tachycardia, a combination of mexiletine + etacizin + propranolol can be used.

With the simultaneous use of Etatsizin and digoxin, the antiarrhythmic effect of the preparations increases and the contractility of the myocardium improves. With their combined use, nausea, anorexia are possible, which is associated with an increase in the concentration of digoxin in the blood plasma. In this case, you need to reduce the dose of digoxin.

The use of glutamic acid in combination with Etacizin eliminates the cardiodepressive effect of the latter in patients with initial signs of circulatory disorders.

Etacizin should not be administered concurrently with MAO inhibitors.

When treating with Etacizin, its interaction with ethanol-containing preparations should be taken into account.

Overdose

Etacizin has a small therapeutic breadth, therefore, severe intoxication can easily occur (especially with the simultaneous use of other antiarrhythmic preparations).

Symptoms: lengthening of the P – R interval and expansion of the QRS complex, an increase in the amplitude of the T waves, bradycardia, sinoatrial and AV blockade, asystole, paroxysms of polymorphic and monomorphic ventricular tachycardia, decreased myocardial contractility, persistent decrease in blood pressure, dizziness, blurred vision, headache, disorders of the gastrointestinal tract.

Treatment: symptomatic; for the treatment of ventricular tachycardia, do not use antiarrhythmic preparations of IA and IC classes; sodium bicarbonate is able to eliminate the expansion of the QRS complex, bradycardia and arterial hypotension.

Storage conditions

At a temperature not exceeding 25 ° c. Keep out of the reach of children.

Tags: Ethacizin

Reviews Ethacizine 50mg 50 tablets — Made in Latvia — Free Delivery

Zhana

This product is such a necessity for me ever since I had to leave my home in Ukraine for Western Europe. I ordered here once and was very satisfied by the shipping system. I hope it will soon be available for me to order again

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