Exforge 10mg/160mg 14 tablets — Made in Spain — Free Delivery
(Exforge)
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Description Exforge 10mg/160mg 14 tablets — Made in Spain — Free Delivery
Product description
Exforge tablets are used for essential hypertension in adult patients whose blood pressure is not regulated by amlodipine or valsartan monotherapy.
Compound
Active ingredients: amlodipine besilate and valsartan;
1 tablet contains amlodipine besylate 6.94 mg in terms of amlodipine base 5 mg and 80 mg of valsartan or amlodipine besylate 6.94 mg in terms of amlodipine base 5 mg and 160 mg of valsartan, or amlodipine besylate 13.87 mg in terms of amlodipine the basis of 10 mg and 160 mg of valsartan;
Excipients: microcrystalline cellulose, crospovidone, magnesium stearate, colloidal silicon dioxide, polyethylene glycol (macrogol) 4000, talc, hypromellose, titanium dioxide (E 171), iron oxide yellow (E172), iron oxide red (E172) - only for tablets 10 mg/160 mg.
Contraindications
- hypersensitivity to the active substance, dihydropyridine derivatives or to any of the excipients of the preparation;
- severe liver dysfunction, biliary cirrhosis or cholestasis;
- simultaneous use of angiotensin receptor antagonists (ARA), including valsartan, or angiotensin-converting enzyme (ACE) inhibitors with aliskiren in patients with diabetes mellitus or with impaired renal function (GFR < 60 mg / minute / 1.73 m 2);
- pregnancy and pregnancy planning;
- severe hypotension;
- shock (including cardiogenic shock);
- obstruction of the outflow tract of the left ventricle (for example, hypertrophic obstructive cardiomyopathy and severe aortic stenosis);
- hemodynamically unstable heart failure after acute myocardial infarction.
Mode of application
Patients whose blood pressure is not adequately controlled by amlodipine or valsartan alone may be switched to combination therapy with Exforge. The recommended dose is one tablet per day. The tablets can be taken with or without food. The preparation is recommended to be taken with a small amount of water.
Patients taking valsartan and amlodipine alone can be switched to Exforge, which contains the same doses of the components.
Before switching to a combination of fixed doses, individual dose selection with components (i.e. amlodipine and valsartan) is recommended. In case of clinical need, direct replacement of monotherapy with a combination with fixed doses can be considered.
Application features
pregnant
The preparation is contraindicated for pregnant women or women planning pregnancy. If pregnancy is confirmed during treatment with this preparation, its use must be immediately discontinued and replaced with another preparation approved for use by pregnant women.
Children
A study of the treatment of children (under the age of 18 years) with this preparation has not been conducted. Therefore, until more information is obtained, Exforge is not recommended for the treatment of children.
Drivers
Patients who use Exforge may experience dizziness or a feeling of weakness after taking the preparation, so they should take this into account when driving vehicles and when working with potentially dangerous mechanisms.
Overdose
There is still no experience of an overdose of Exforge. The main symptom of an overdose of valsartan is probably severe arterial hypotension with dizziness. An overdose of amlodipine can lead to progressive peripheral vasodilation and possibly reflex tachycardia. Significant and potentially prolonged systemic hypotension, up to shock and death, has been reported.
If the preparation has been taken recently, induce vomiting or gastric lavage. The absorption of amlodipine is significantly reduced when activated charcoal is used immediately or within two hours after taking amlodipine.
Side effects
The safety of Exforge was evaluated in 5 controlled clinical trials involving 5175 patients, 2613 of whom received valsartan in combination with amlodipine. Adverse reactions that were observed most often or were significant or severe: nasopharyngitis, influenza, hypersensitivity, headache, syncope, orthostatic hypotension, edema, soft tissue edema, facial edema, peripheral edema, increased fatigue, facial flushing, asthenia and hot flashes.
Interaction
Aliskiren. In patients with diabetes mellitus or patients with impaired renal function, the risk of hyperkalemia, deterioration of renal function and cardiovascular morbidity and mortality is increased.
Medicines that cause hyperkalemia. Some preparations or therapeutic classes of preparations can cause hyperkalemia, namely: aliskiren, potassium salts, potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, non-steroidal anti-inflammatory preparations (NSAIDs), heparin, immunosuppressants such as cyclosporine or tacrolimus, trimethoprim. The simultaneous use of these preparations increases the risk of hyperkalemia.
Storage conditions
Store in the original packaging at a temperature not exceeding 30°C, protected from moisture and out of the reach of children.
Shelf life - 3 years.
Tags: Exforge
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