Galazolin nasal gel 0.05%, 2p x 10g — Made in Poland — Free Delivery

Pharmacological properties

Pharmacodynamics. Xylometazoline - an imidazoline derivative, has a sympathomimetic effect, is a direct antagonist of α2-adrenergic receptors. causes a narrowing of the blood vessels of the nasal mucosa, eliminates hyperemia and edema, and reduces exudation.

Prolonged use of the preparation (2 weeks) can lead to secondary dilation of blood vessels (preparation -induced rhinitis), which can be caused by inhibition of the release of norepinephrine from nerve endings by excitation of presynaptic α2-adrenergic receptors.

Pharmacokinetics. The preparation develops in 5-10 minutes; its effect lasts for 5-6 hours, but vasoconstriction persists for 8-12 hours. When applied to the mucous membrane, the preparation causes local narrowing of blood vessels and is practically not absorbed into the bloodstream and has no systemic effect. If a significant amount of xylometazoline enters the digestive tract (mostly possible in children), excessive sedation is noted.

Indications

Treatment of acute rhinitis of viral or bacterial origin; acute or exacerbation of chronic sinusitis; allergic rhinitis; acute otitis media (to restore the patency of the auditory tubes).

Application

Nasal drops 0.05% (1 drop contains 0.025 mg of xylometazoline hydrochloride).

For children aged 4 months to 2 years, according to the doctor's prescription, 1 drop of 0.05% solution is instilled into each nasal passage every 8-12 hours; but no more than 3 times a day; children aged 2-12 years - 2-3 drops of 0.05% solution in each nasal passage every 8-10 hours.

Nasal drops 0.1% (1 drop contains 0.05 mg of xylometazoline hydrochloride).

Adults and children over the age of 12 are instilled 2-3 drops into each nasal passage every 8-10 hours.

The preparation in the form of 0.05 and 0.1% nasal gel is applied to the mucous membrane of the nasal cavity by a quick one-time pressing of the bottle dispenser.

Each time before using the preparation, you must remove the nozzle and press the dispenser 3-5 times until the preparation  (gel) appears.

0.05% nasal gel (one press contains 0.05 mg xylometazoline hydrochloride).

Children aged 3–12 years: 0.05% nasal gel: Typically, one press into each nasal passage every 8–10 hours.

Nasal gel 0.1% (one press contains 0.1 mg of xylometazoline hydrochloride) is prescribed for adults and children over the age of 12 years.

Children over the age of 12 and adults: Typically give one press to each nasal passage every 8-10 hours.

The course of treatment is usually 3-5 days and in any case should not exceed 10 days.

Contraindications

Hypersensitivity to the components of the preparation; period of pregnancy; angle-closure glaucoma; condition after hypophysectomy or other surgical interventions carried out with an incision in the dura mater. children under the age of 4 months - in the form of drops.

Side effects

Locally, in some cases, there may be irritation, burning, an unpleasant sensation of dryness of the nasal mucosa, sneezing. very rarely there is a systemic effect - headache, drowsiness, weakness, dizziness, tachycardia, nausea, short-term visual impairment, allergic reactions (rash, angioedema), heart rhythm disturbances, increased blood pressure (especially in patients with diseases of the cardiovascular system), dyspnea. in the case of a very high dose or mistaken application, the drops can be swallowed, which leads to the absorption of the active substance into the gastrointestinal tract. such cases are noted mainly in children, with the main side effect being excessive sedation.

special instructions

The bottle must be used individually; it should not be passed on to others for use to prevent possible spread of infection.

In chronic rhinitis, the preparation should not be used continuously for a long time (more than 10 days). The use of the preparation for more than 10 days can cause rhinitis medicamentosa. Long-term use of the preparation can cause the opposite effect. Do not exceed the recommended dose of the preparation, especially when treating children and the elderly.

The preparation in the form of nasal drops should not be used in children under 4 months of age. The preparation in the form of a nasal gel should not be used in children under the age of 3 years.

Use with caution in patients with coronary artery disease, hypertension, diabetes mellitus, angle-closure glaucoma, thyroid diseases, prostatic hypertrophy, hyperthyroidism. Do not use the preparation during treatment with MAO inhibitors or tricyclic antidepressants.

The preparation  can be used during pregnancy only if the expected therapeutic effect for the mother outweighs the potential risk to the fetus.

There is no evidence that Galazolin is excreted in breast milk, however, it is not recommended to use the preparation  during breastfeeding. If the use of the preparation  is necessary, breastfeeding should be discontinued.

The ability to influence the reaction rate when driving or operating other mechanisms. The preparation does not adversely affect the ability to drive vehicles and work with potentially dangerous mechanisms.

Interactions

Due to the fact that the preparation enters the systemic circulation in a minimal amount, it is unlikely to interact with other preparations used. noted individual cases of preparation interaction with tricyclic antidepressants, therefore, the preparation  is not used during treatment with tricyclic antidepressants and MAO inhibitors. do not use simultaneously with other sympathomimetics (eg ephedrine, pseudoephedrine), given the mutual enhancement of the preparations.

Overdose

A significant overdose of the preparation or its accidental oral intake, especially by children, can cause the development of a sedative effect, visual impairment, headache, irritability, increased blood pressure, heart rhythm disturbances, insomnia, respiratory depression, and disturbances of consciousness. long-term use of the preparation can lead to the development of secondary preparation-induced rhinitis, resistant to therapy. overdose treatment is symptomatic.

Storage conditions

In the dark place at room temperature 15-25 ° C. Keep out of the reach of children.