L-Thyroxine-Farmak 25mcg, 2p x 50 tablets — Made in Ukraine — Free Delivery

Thyroid hormone preparation. Synthetic levorotatory isomer of thyroxine. In small doses, it has anabolic effect. In medium doses, it stimulates growth and development, increases tissue oxygen demand, stimulates the metabolism of proteins, fats and carbohydrates, stimulates the activity of the cardiovascular system and the central nervous system. In high doses, it inhibits the production of TSHR of the hypothalamus and TSH of the pituitary gland.

After oral administration, it is absorbed from the gastrointestinal tract, absorption is 48-79%. Taking on an empty stomach increases the absorption of the active substance. Cmax in plasma is achieved after about 6 hours. Plasma protein binding (thyroxine-binding globulin, thyroxine-binding prealbumin and albumin) is more than 99%. Vd is 0.5 l / kg. Distribution occurs mainly in the liver, brain and muscles.

In various tissues, monodeiodination of approximately 80% of sodium levothyroxine occurs with the formation of triiodothyronine (T3) and inactive products. A small amount of the active substance undergoes deamination and decarboxylation with the formation of tetraiodothyroacetic acid, as well as conjugation with sulfuric and glucuronic acids (in the liver).

T1 / 2 is 6-7 days. About 15% is excreted by the kidneys and bile in unchanged form and in the form of conjugates.

Indications of the active substances of the preparation L-Tyroxin-Farmak

Hypothyroidism; euthyroid goiter; as replacement therapy and for the prevention of recurrence of goiter after resection of the thyroid gland; thyroid cancer (after surgery); diffuse toxic goiter: after reaching the euthyroid state with antithyroid preparations (in the form of combination or monotherapy); as a diagnostic tool when performing a thyroid suppression test.

The method of application and dosage regimen of a particular preparation depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular preparation with the indications for use and the dosage regimen.

Set individually depending on the indications. Applied at a dose of 12.5-200 mcg 1 time / day 20-30 minutes before meals.

When conducting a differential diagnostic test of thyroid suppression - once at a dose of 3 mg or within 2 weeks, 200 μg 1 time / day.

Symptoms of hyperthyroidism: possible (when used in high doses, including when the dose is increased too quickly at the beginning of the course of treatment) tachycardia, palpitation, arrhythmias, angina attacks, headache, nervousness, tremor, sleep disturbances, feeling of internal anxiety, muscle weakness and cramps, weight loss, diarrhea, menstrual irregularities, vomiting.

Hypersensitivity to levothyroxine sodium; untreated thyrotoxicosis; acute myocardial infarction, acute myocarditis; untreated adrenal cortex insufficiency.

With care: in diseases of the cardiovascular system - coronary artery disease (atherosclerosis, angina pectoris, myocardial infarction in history), arterial hypertension, arrhythmias; with diabetes mellitus, severe long-term hypothyroidism, malabsorption syndrome (dose adjustment may be required).

Application during pregnancy and lactation

During pregnancy and lactation (breastfeeding), levothyroxine sodium should be used with caution, strictly in recommended doses, under medical supervision.

The use in combination with thyrostatic agents during pregnancy is contraindicated due to the increased risk of hypothyroidism in the fetus.

It is possible to use in children according to indications in doses and dosage forms recommended according to age.

In elderly patients and with prolonged hypothyroidism, treatment should be started gradually.