Lesfal solution for injection 50 mg/ml, 5ml x 5 pcs — Made in Ukraine — Free Delivery

Pharmacological properties

Pharmacodynamics. Phospholipids contained in the preparation are similar in chemical structure to endogenous phospholipids, but much exceed them in terms of the content of polyunsaturated (essential) fatty acids. these high-energy molecules are incorporated predominantly into the structures of cell membranes and facilitate the repair of damaged liver tissue. phospholipids affect the disturbed lipid metabolism by regulating lipoprotein metabolism, as a result of which neutral fats and xc are converted into forms suitable for transport, especially due to an increase in the ability of lpvp to attach xc, and are intended for further oxidation. during the excretion of phospholipids through the biliary tract, the lithogenic index decreases and bile stabilizes.

Pharmacokinetics. T1 / 2 for the choline component is 66 hours, for saturated fatty acids - 32 hours.

In studies of kinetics in the human body, 5% of each of the administered isotopes 3H and 14C were excreted in the feces.

Indications

Fatty liver degeneration, acute and chronic hepatitis, cirrhosis of the liver, pre- and postoperative treatment of a patient with surgery on the liver and biliary tract, toxic liver damage, toxicosis of pregnant women, psoriasis, radiation syndrome.

Application

Only transparent solution should be used.

The preparation is administered intravenously slowly. You can not enter the preparation in / m due to the possible occurrence of a local reaction.

Adults and children over the age of 12 are prescribed IV slowly 5-10 ml / day, and in severe cases - 10-20 ml / day. It is allowed to inject 10 ml of the preparation at a time. To dilute the preparation, it is recommended to use the patient's own blood in a 1: 1 ratio. The course of treatment is up to 10 days, followed by a switch to oral forms of phosphatidylcholine.

Treatment for psoriasis begins with oral phosphatidylcholine for 2 weeks. After that, 10 IV injections of 5 ml are recommended with the simultaneous appointment of PUVA therapy. After the end of the course of injections, oral forms of phosphatidylcholine are resumed.

In cases where it is impossible to use the patient's own blood to dilute the preparation, solutions free of electrolytes should be used - 5% or 10% glucose solution, 5% xylitol solution in a 1: 1 ratio.

Contraindications

Hypersensitivity to any of the components of the preparation.

Side effects

In some cases, when using the preparation in higher doses, disorders of the digestive tract (diarrhea) are possible. in some cases, hypersensitivity reactions, rash, itching may occur.

Special instructions

Precautions: solution contains 5.02 mg / ml of alcohol. for IV use only.

Use during pregnancy and lactation. The preparation is used to eliminate toxicosis in pregnant women.

The preparation is not contraindicated for use during lactation.

Children. The preparation is prescribed for the treatment of children over the age of 12 years.

The ability to influence the reaction rate when driving or working with other mechanisms. Not identified.

Interactions

Interactions with other preparations have not been studied. the preparation is incompatible with electrolyte solutions. do not inject the preparation together with other preparations in the same syringe.

Overdose

There have been no reports of overdose.

Storage conditions

In the dark place at a temperature of 2-8 ° c.