Limistin 40, 40mg 30 tablets — Made in India — Free Delivery

Product description

Film-coated tablets Limistin 40 are indicated for:

• preventing cardiovascular disease;
• reducing the risk of myocardial infarction;
• reducing the risk of stroke;
• reducing the risk of revascularization procedures and angina pectoris.
• reducing the risk of non-fatal myocardial infarction;
• reducing the risk of fatal and non-fatal stroke;
• reducing the risk of hospitalization due to congestive heart failure.

Compound

Active substance: atorvastatin;

1 tablet contains atorvastatin calcium in terms of atorvastatin 10 mg or 20 mg, 40 mg;

Excipients: calcium carbonate; microcrystalline cellulose lactose monohydrate, croscarmellose sodium; polysorbate 80 hydroxypropyl cellulose; magnesium stearate hydroxypropyl methylcellulose; propylene glycol; polyethylene glycol-6000; talc titanium dioxide (E 171) - tablets of 10 mg and 20 mg

Calcium carbonate; microcrystalline cellulose lactose monohydrate, croscarmellose sodium; polysorbate 80 hydroxypropyl cellulose; magnesium stearate crospovidone; sodium lauryl sulfate; hydroxypropyl methylcellulose; polyethylene glycol-6000; talc titanium dioxide (E 171) - 40 mg tablets.

Contraindications

Active liver disease, which may include a sustained increase in hepatic transaminase activity of unknown etiology.

Hypersensitivity to any of the components of this medication.

Mode of application

Before starting therapy with atorvastatin, the level of hypercholesterolemia should be determined against the background of an appropriate diet, exercise and measures aimed at reducing body weight in obese patients should be prescribed, and other diseases should be treated. During treatment with atorvastatin, patients should follow a standard low-cholesterol diet. Use the preparation in a dose of 10-80 mg once a day every day, at any time of the day, regardless of food intake. The starting and maintenance dose can be individualized according to the starting level of LDL-C, the goals of therapy and its effectiveness. 2-4 weeks after the start of treatment and / or dose adjustment of atorvastatin, the lipid profile should be determined and the dose adjusted accordingly.

Application features

Pregnant

Not applicable.

Children

From 10 years old.

Drivers

Has a very insignificant effect on the reaction rate when driving or working with other mechanisms.

Overdose

There is no specific treatment for atorvastatin overdose. In case of an overdose, the patient should be treated symptomatically and supportive measures should be taken if necessary. Due to the high degree of binding of the preparation to plasma proteins, one should not expect a significant increase in the clearance of atorvastatin using hemodialysis.

Side effects

Atorvastatin is generally well tolerated.

Adverse reactions include: chest pain, facial edema, fever, asthenia, stiff neck muscles, weakness, photosensitivity, generalized edema, malaise, pyrexia, peripheral edema.

Interaction

The risk of developing myopathy during treatment with statins increases with the simultaneous use of fibric acid derivatives, lipid-modifying doses of niacin, cyclosporine, or potent inhibitors of CYP 3A4 (for example, clarithromycin, HIV protease inhibitors and itraconazole).

Grapefruit juice. Contains one or more components that inhibit CYP 3A4 and can increase plasma concentrations of atorvastatin, especially with excessive consumption of grapefruit juice (more than 1.2 liters per day).

Atorvastatin and its metabolites are substrates for the OATP1B1 transporter. OATP1B1 inhibitors (eg cyclosporin) can increase the bioavailability of atorvastatin. The AUC value of atorvastatin significantly increased with the simultaneous use of atorvastatin at a dose of 10 mg and cyclosporin at a dose of 5.2 mg / kg / day compared with the use of atorvastatin alone. The simultaneous use of atorvastatin and cyclosporine should be avoided.

Storage conditions

Store in its original packaging at a temperature not exceeding 30 ° C.

Keep out of the reach of children.

Shelf life is 2 years.