Lisinopril-Teva 10 mg 60 tablets — Made in Czech Republic — Free Delivery

Product description

Lisinopril-Teva tablets are used for the following indications:

• Arterial hypertension.
• Heart failure.
• Acute myocardial infarction in patients with stable hemodynamic parameters (systolic blood pressure> 100 mm Hg).
• Complications of the kidneys in diabetes mellitus (treatment of kidney disease in hypertensive patients with type II diabetes mellitus and initial nephropathy).

Structure

Active substance: lisinopril;

1 tablet contains 5 mg or 10 mg or 20 mg of lisinopril in the form of lisinopril dihydrate;

Excipients: mannitol (E 421), calcium hydrogen phosphate, corn starch, croscarmellose sodium, magnesium stearate for tablets of 10 mg and 20 mg iron oxide yellow (E172), iron oxide black (E172), iron oxide red

(E 172).

Contraindications

Hypersensitivity to lisinopril, other components of the preparation or other ACE inhibitors.

A history of angioedema (including after the use of ACE inhibitors, idiopathic and hereditary Quincke's edema).

Aortic or mitral stenosis or hypertrophic cardiomyopathy with severe hemodynamic disturbances.

Bilateral renal artery stenosis or stenosis of a solitary kidney artery.

Acute myocardial infarction with unstable hemodynamics.

Cardiogenic shock.

Patients with serum creatinine levels ≥220 μmol / L.

Simultaneous use of the preparation and high-throughput membranes polyacrylonitrile sodium-2-methylsulfonate (for example, AN69) for urgent dialysis.

Simultaneous use of aliskiren-containing preparations in patients with diabetes mellitus or impaired renal function (GFR <60 ml / min / 1.73 m 2).

Primary hyperaldosteronism.

Pregnant women or women planning to become pregnant.

Simultaneous use with sacubitril / valsartan. Treatment with Lisinopril-Teva can be started only 36 hours after taking the last dose of Sakubitril / Valsartan.

Mode of application

Lisinopril must be taken orally once a day. Like other preparations that should be taken once a day, lisinopril must be taken every day at about the same time. Food intake does not affect the absorption of lisinopril tablets. The dose should be determined individually in accordance with the patient's clinical data and blood pressure indicators.

Application features

Pregnant

Contraindicated.

Children

The safety and efficacy of lisinopril in children have not been established, therefore, the preparation should not be prescribed for this age group of patients.

Drivers

It is necessary to take into account the possibility of dizziness and increased fatigue, which may affect the ability to drive vehicles or other mechanisms.

Overdose

Symptoms: arterial hypotension, circulatory shock, electrolyte disturbances, renal failure, hyperventilation, tachycardia, palpitations, bradycardia, dizziness, anxiety and cough.

Treatment: intravenous administration of saline solutions. With arterial hypotension, the patient should be placed on his back with his legs raised up. If possible, angiotensin II infusion and / or intravenous catecholamines are given. If the preparation is recently taken, gastric lavage, the use of absorbents and sodium sulfate are indicated. For the treatment of persistent bradycardia, the use of a pacemaker is indicated.

Continuous monitoring of laboratory parameters (determination of the level of electrolytes and serum creatinine) and vital functions is recommended.

Lisinopril can be removed from the body by hemodialysis, and the use of polyacrylonitrile metal sulfonate high-flow membranes (eg AN69) should be avoided.

In the case of angioedema, antihistamines are prescribed. If the clinical situation is accompanied by edema of the tongue, glottis, larynx, it is necessary to urgently begin treatment by transdermal administration of 0.3-0.5 ml of adrenaline solution (1: 1000), intubation or laryngotomy is indicated to ensure airway patency.

Side effects

From the side of the blood system: a decrease in the level of hemoglobin and hematocrit, inhibition of bone marrow activity, anemia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease.

From the side of metabolism: hypoglycemia.

From the side of the central nervous system: dizziness, headache, mood changes, paresthesia, impaired taste, sleep disturbance, imbalance, disorientation, confusion, impaired scent, symptoms of depression, fainting.

From the cardiovascular system: orthostatic effect (including arterial hypotension), myocardial infarction or cerebrovascular stroke, possibly secondary due to excessive arterial hypotension in high-risk patients, palpitation, tachycardia, Raynaud's phenomenon.

From the musculoskeletal system: muscle spasms have been reported.

From the respiratory system: cough, bronchitis, rhinitis, shortness of breath, dyspnea, angioedema, bronchospasm, glossitis, sinusitis, allergic alveolitis / eosinophilic pneumonia. Upper respiratory tract infections have been reported.

From the digestive tract: diarrhea, vomiting, nausea, abdominal pain, dyspepsia, dry mouth, decreased appetite, taste changes, pancreatitis, intestinal angioedema, constipation, hepatitis (hepatocellular or cholestatic), jaundice and liver failure.

On the part of the skin: rash, itching, hypersensitivity / angioedema of the face, extremities, lips, tongue, glottis and / or pharynx, fever, skin flushing, urticaria, alopecia, psoriasis, increased sweating, pemphigus, toxic epidermal necrolysis, Stevens syndrome -Johnson, erythema polymorph, skin lymphocytoma.

A syndrome has been reported that includes one or more symptoms: fever, vasculitis, myalgia, arthralgia / arthritis, the appearance of positive antinuclear antibodies, accelerated erythrocyte sedimentation rate, eosinophilia and leukocytosis, rashes, photosensitization or other skin manifestations.

From the urinary system: renal dysfunction, uremia, acute renal failure, oliguria / anuria.

From the endocrine system: inadequate secretion of antidiuretic hormone.

Reproductive system disorders: impotence, gynecomastia.

General disorders: increased fatigue, weakness.

Interaction

The simultaneous use of the preparation and high-throughput membranes with polyacrylonitrile sodium-2-methylsulfonate (for example AN 69) during urgent dialysis is contraindicated.

ACE inhibitors potentiate the effect of ethanol. Ethanol increases blood pressure by decreasing the effect of ACE inhibitors.

Simultaneous use with sacubitril / valsartan is contraindicated. Treatment with Lisinopril-Teva can be started only 36 hours after taking the last dose of Sakubitril / Valsartan.

Storage conditions

The preparation does not require special storage conditions.

Keep out of the reach of children.

Shelf life is 4 years.