Magnerot 500mg 20 tablets — Made in Germany — Free Delivery

Pharmacological properties

Pharmacodynamics. Magnesium preparation. Magnesium is a macronutrient, an important intracellular cation. takes part in reactions involving over 300 enzymes, in the regulation of cell permeability and neuromuscular transmission. magnesium is necessary for many energy processes, participates in the metabolism of proteins, fats, carbohydrates and nucleic acids, is a natural physiological calcium antagonist. controls the normal functioning of myocardial cells; takes part in the regulation of its contractile function; can reduce peripheral vascular resistance, improve coronary circulation. together with the elimination of the symptoms of magnesium deficiency, magnesium demonstrates a curariform effect on cholinergic nerve endings due to a decrease in the release of acetylcholine, and can inhibit platelet aggregation.

Magnesium orotate promotes tissue regeneration, takes part in the metabolic process. In addition, the orotic acid derivative is necessary for the fixation of magnesium on ATP in the cell and the manifestation of its action, and also accelerates the regeneration processes, improves the synthesis of pyrimidine bases, the synthesis of nucleic acids.

Pharmacokinetics. Magnesium orotate exhibits a very low level of dissociation. Only after entering the cell is this substance broken down into components.

About 55% of magnesium is in ionized form, 32% binds to proteins, mainly albumin, α1- and β2-globulins, and 13% is contained in the form of salts, mainly in the form of phosphates and citrates.

About 60% of total magnesium accumulates in bone tissues, 40% - in the intracellular space and about 1% is located in the extracellular fluid. This is one of the reasons why it is impossible to draw conclusions about the total magnesium balance in the body based on the determination of the level of magnesium in the blood.

90% of the magnesium that accumulates inside cells binds to ATP in the cytosol, RNA in ribosomes and DNA in cell nuclei. ATP deficiency, for example, leads to a loss of magnesium. Orotic acid is able to increase the ATP content and therefore acts as a magnesium fixer in cells. Orotic acid is metabolized into uridine monophosphate, which is an intermediate product of pyrimidine metabolism.

Magnesium is excreted in both feces and urine. Also, it is excreted through sweat. Penetrates into breast milk.

Indications

Conditions accompanied by magnesium deficiency, as well as in complex treatment and for the prevention of ischemic heart disease (angina pectoris, myocardial infarction), angiospasm; lipid metabolism disorders, atherosclerosis, arteriolitis, arteritis.

Application

Prescribe 2 tablets 3 times a day for 7 days, then 1 tablet 2-3 times a day. the duration of the course of treatment is at least 6 weeks. the maximum daily dose of the preparation Magnerot is 6 tablets (3000 mg of magnesium orotate dihydrate).

Magnerot is taken 1 hour before meals. The tablets should be taken with a small amount of liquid (1 glass of water).

Contraindications

Hypersensitivity to the components of the preparation. hypermagnesemia, hypocalcemia, urolithiasis (phosphate and calcium-magnesium calculi), impaired renal function, severe bradycardia and av-blockade (i – ii degrees).

Side effects

From the gastrointestinal tract: gastrointestinal disturbances (diarrhea or poorly formed stools).

Others: possible allergic reactions, skin rash.

Special instructions

Magnerot is used for magnesium deficiency. it should be borne in mind that gastrointestinal diseases, the use of foods with a reduced magnesium content, chronic alcoholism (due to a decrease in the resorption of magnesium in the renal tubules and increased excretion of magnesium from the body), taking certain medications (oral contraceptives, containing estrogens, diuretics, muscle relaxants, corticosteroids, insulin), conditions that require increased magnesium intake (physical inactivity, stress, sports, pregnancy). Taking vitamin D supplements can interfere with calcium metabolism and cause magnesium imbalances. this can occur with prolonged exposure to the sun. with simultaneous treatment with iron preparations, tetracycline, sodium fluoride, the interval between taking magnesium preparations and these preparations should be 2-3 hours. Since the preparation contains lactose, it should not be used in case of hereditary galactose intolerance, lactase deficiency, or impaired glucose-galactose malabsorption.

Use during pregnancy and lactation. The use of the preparation during pregnancy and lactation is possible, since during this period the need for magnesium increases significantly. If its content in the body is not balanced, it can lead to serious complications for both the mother and the baby.

Children. The efficacy and safety of the preparation in children have not been established, so the preparation should not be prescribed to this age category.

The ability to influence the reaction rate when driving or working with other mechanisms. There are no particular caveats, but it should be borne in mind that magnesium has a sedative effect on the central nervous system.

Interactions

Magnesium, which is part of Magnerot, when taken simultaneously, makes it difficult for the absorption of iron, tetracycline and sodium fluoride.

As a preparation, magnesium can enhance the effect of preparations that depress the central nervous system (sedatives, antipsychotics, tranquilizers), as well as antiarrhythmic, antihypertensive preparations.

Reduces the severity of magnesium deficiency and reduces the risk of related complications when taking diuretics, aminoglycosides, cisplatin, cyclosporine, amphotericin, methotrexate, laxatives.

Overdose

With full renal function, magnesium intoxication is rare.

With magnesium intoxication, symptoms from the central nervous system are noted (nausea, vomiting, urinary obstruction, constipation, paralysis of the respiratory system) and cardiac symptoms (deterioration of atrioventricular conduction and excitation from the ventricles), as well as a curariform effect on neuromuscular conduction. Magnesium intoxication is treated by intravenous administration of calcium (100-200 mg Ca2 + for 5-10 minutes). Additionally, hemodialysis, peritoneal dialysis and artificial respiration may be needed.

Storage conditions

In its original packaging at a temperature not exceeding 25 ° C.