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The following adverse reactions are classified by frequency: very often (≥1 / 10), often (from ≥1 / 100 to 1/10), infrequently (from ≥1 / 1000 to 1/100), rarely (from ≥ 1 / 10,000 up to 1/1000), very rarely (1/10,000).

Gastrointestinal disorders: often - nausea and dyspepsia.

Nervous system disorders: often - headache. The incidence of headache in the placebo group (5.9% of 457 patients) was similar to that in the betahistine group (5.1% of 468 patients).

Except for cases reported during clinical trials, the following side effects have been reported spontaneously during post-marketing use and in the scientific literature. Based on the available data, the frequency cannot be determined, so it is classified as unknown.

Immune system disorders. Hypersensitivity reactions, including immediate type (for example, cases of anaphylaxis have been reported).

Gastrointestinal disorders. Complaints of minor indigestion (vomiting, pain along the gastrointestinal tract, pain in the abdominal region due to bloating and flatulence). These side effects usually disappear when the preparation is taken with food or when the dose is reduced.

Changes in the skin and subcutaneous tissue. Hypersensitivity reactions of the skin and subcutaneous fat have been observed, in particular angioedema, rash, itching and urticaria.

During treatment with the preparation, it is necessary to carefully monitor the condition of patients with asthma and / or a history of gastric ulcer and duodenal ulcer.

The preparation contains lactose, so it should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Betahistine, according to clinical studies, has no significant effect or effects that affect the ability to drive and operate machines.

Use during pregnancy or lactation. There are no data on the use of betahistine in pregnant women. Since studies of reproductive toxicity in animals do not always allow us to assess the possibility of toxic effects on pregnancy, embryo / fetus development, childbirth and postnatal development in humans, the preparation should be taken only if there is an undeniable need and under the direct supervision of a physician.