Metformin-Teva 1000 mg | Buy Online & Product Guide

(Metformin-Teva)
Metformin-Teva 1000 mg | Buy Online & Product Guide
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TEVA Brand: TEVA
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Description Metformin-Teva 1000 mg | Buy Online & Product Guide

Metformin-Teva 1000 mg is a potent, high-dose oral hypoglycemic preparation belonging to the biguanide class. It is specifically formulated to manage Type 2 Diabetes Mellitus in patients whose blood glucose levels are not adequately controlled by diet and physical exercise alone. This medication is the gold standard first-line therapy for patients with excess body weight, as it effectively reduces long-term diabetic complications. Metformin-Teva 1000 mg can be used as a standalone monotherapy or as part of a complex treatment plan involving other oral antidiabetics or insulin for adults and children over 10 years of age.

Composition and Active Substance

Each film-coated tablet is manufactured to high pharmaceutical standards:

  • Active Substance: Metformin hydrochloride — 1000 mg.

  • Excipients: Povidone K-30, anhydrous colloidal silicon dioxide, magnesium stearate.

  • Film Coating (White Opadry Y-1-7000): Hypromellose, titanium dioxide (E 171), and macrogol.

Pharmacological Action

Metformin-Teva 1000 mg lowers blood glucose through three targeted biological mechanisms that do not involve stimulating additional insulin production:

  1. Hepatic Control: It significantly reduces the liver’s production of glucose by inhibiting gluconeogenesis and glycogenolysis.

  2. Muscle Sensitivity: It enhances the peripheral sensitivity of skeletal muscles to insulin, allowing for more efficient glucose uptake and utilization.

  3. Absorption Modulation: It delays the absorption of glucose within the intestinal tract.

Because it does not trigger insulin secretion, it has a very low risk of causing hypoglycemia when used alone and is often "weight-neutral," helping overweight patients stabilize or lose weight.

Indications for Use

  • Type 2 Diabetes Mellitus: Primary treatment for adults and adolescents (10+ years).

  • Overweight Management: First-line therapy to reduce vascular and metabolic complications.

  • Combined Therapy: Effective when paired with insulin or other oral hypoglycemic drugs.

Contraindications

  • Hypersensitivity to metformin or any tablet components.

  • Severe Renal Impairment: Glomerular filtration rate (GFR) < 30 ml/min.

  • Metabolic Acidosis: Including acute lactic acidosis or diabetic ketoacidosis.

  • Hypoxia Risks: Decompensated heart failure, respiratory failure, or recent myocardial infarction.

  • Acute Conditions: Dehydration, severe infections, or shock.

  • Liver Health: Liver failure, acute alcohol intoxication, and alcoholism.

Dosage and Administration

Adults:

  • Initial Dose: Usually 500 mg or 850 mg (using appropriate strengths) 2–3 times daily.

  • Titration: Adjust after 10–15 days based on blood glucose levels.

  • Maximum Dose: 3000 mg per day, divided into 3 doses.

Children (10+ Years):

  • Initial Dose: 500 mg or 850 mg once daily.

  • Maximum Dose: 2000 mg per day, divided into 2–3 doses.

Special Administration Tips

  • Meal Coordination: Always take your tablets during or after meals to minimize digestive discomfort.

  • Swallowing: High-dose 1000 mg tablets should be swallowed whole with water.

Side Effects and Adverse Reactions

  • Gastrointestinal (Very Common): Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These usually occur at the start of treatment and fade away.

  • Nervous System: Taste disturbances (metallic taste).

  • Metabolic: Rare risk of Lactic Acidosis. Long-term use may slightly decrease Vitamin B12 absorption.

Special Precautions & Warnings

  • Lactic Acidosis: A medical emergency characterized by muscle cramps and weakness. Avoid excessive alcohol and dehydration.

  • Pregnancy: While metformin is safe, switching to insulin is typically recommended to achieve the strictest possible blood sugar control for fetal health.

  • Breastfeeding: Not recommended as metformin is excreted in breast milk.

  • Driving: Safe in monotherapy; however, caution is required if combined with insulin or sulfonylureas due to potential hypoglycemia.

Storage Conditions and Shelf Life

  • No special temperature storage conditions are required.

  • Keep out of the reach of children.

  • Shelf Life: 3 years.

Tags: Metformin

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