Metformin-Teva 1000 mg | Buy Online & Product Guide
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Description Metformin-Teva 1000 mg | Buy Online & Product Guide
Metformin-Teva 1000 mg is a potent, high-dose oral hypoglycemic preparation belonging to the biguanide class. It is specifically formulated to manage Type 2 Diabetes Mellitus in patients whose blood glucose levels are not adequately controlled by diet and physical exercise alone. This medication is the gold standard first-line therapy for patients with excess body weight, as it effectively reduces long-term diabetic complications. Metformin-Teva 1000 mg can be used as a standalone monotherapy or as part of a complex treatment plan involving other oral antidiabetics or insulin for adults and children over 10 years of age.
Composition and Active Substance
Each film-coated tablet is manufactured to high pharmaceutical standards:
Active Substance: Metformin hydrochloride — 1000 mg.
Excipients: Povidone K-30, anhydrous colloidal silicon dioxide, magnesium stearate.
Film Coating (White Opadry Y-1-7000): Hypromellose, titanium dioxide (E 171), and macrogol.
Pharmacological Action
Metformin-Teva 1000 mg lowers blood glucose through three targeted biological mechanisms that do not involve stimulating additional insulin production:
Hepatic Control: It significantly reduces the liver’s production of glucose by inhibiting gluconeogenesis and glycogenolysis.
Muscle Sensitivity: It enhances the peripheral sensitivity of skeletal muscles to insulin, allowing for more efficient glucose uptake and utilization.
Absorption Modulation: It delays the absorption of glucose within the intestinal tract.
Because it does not trigger insulin secretion, it has a very low risk of causing hypoglycemia when used alone and is often "weight-neutral," helping overweight patients stabilize or lose weight.
Indications for Use
Type 2 Diabetes Mellitus: Primary treatment for adults and adolescents (10+ years).
Overweight Management: First-line therapy to reduce vascular and metabolic complications.
Combined Therapy: Effective when paired with insulin or other oral hypoglycemic drugs.
Contraindications
Hypersensitivity to metformin or any tablet components.
Severe Renal Impairment: Glomerular filtration rate (GFR) < 30 ml/min.
Metabolic Acidosis: Including acute lactic acidosis or diabetic ketoacidosis.
Hypoxia Risks: Decompensated heart failure, respiratory failure, or recent myocardial infarction.
Acute Conditions: Dehydration, severe infections, or shock.
Liver Health: Liver failure, acute alcohol intoxication, and alcoholism.
Dosage and Administration
Adults:
Initial Dose: Usually 500 mg or 850 mg (using appropriate strengths) 2–3 times daily.
Titration: Adjust after 10–15 days based on blood glucose levels.
Maximum Dose: 3000 mg per day, divided into 3 doses.
Children (10+ Years):
Initial Dose: 500 mg or 850 mg once daily.
Maximum Dose: 2000 mg per day, divided into 2–3 doses.
Special Administration Tips
Meal Coordination: Always take your tablets during or after meals to minimize digestive discomfort.
Swallowing: High-dose 1000 mg tablets should be swallowed whole with water.
Side Effects and Adverse Reactions
Gastrointestinal (Very Common): Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These usually occur at the start of treatment and fade away.
Nervous System: Taste disturbances (metallic taste).
Metabolic: Rare risk of Lactic Acidosis. Long-term use may slightly decrease Vitamin B12 absorption.
Special Precautions & Warnings
Lactic Acidosis: A medical emergency characterized by muscle cramps and weakness. Avoid excessive alcohol and dehydration.
Pregnancy: While metformin is safe, switching to insulin is typically recommended to achieve the strictest possible blood sugar control for fetal health.
Breastfeeding: Not recommended as metformin is excreted in breast milk.
Driving: Safe in monotherapy; however, caution is required if combined with insulin or sulfonylureas due to potential hypoglycemia.
Storage Conditions and Shelf Life
No special temperature storage conditions are required.
Keep out of the reach of children.
Shelf Life: 3 years.
Tags: Metformin
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