Muskomed solution for injection 4 mg/2 ml, 6 ampoules — Made in Turkey — Free Delivery

(Muskomed)
Muskomed solution for injection 4 mg/2 ml, 6 ampoules — Made in Turkey — Free Delivery
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Mefar Ilac San. A.S. Brand: Mefar Ilac San. A.S.
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Description Muskomed solution for injection 4 mg/2 ml, 6 ampoules — Made in Turkey — Free Delivery

Pharmacological properties

Pharmacodynamics. Muskomed contains the active ingredient thiocolchicoside, a semi-synthetic muscle relaxant, which is obtained from the natural glycoside colchicoside. exhibits selective affinity for gamma and glycine receptors, which determines the effect of the preparation at various levels of the nervous system, both in spasms of a local nature and in spasms of central origin.

Muskomed does not have a curariform effect, does not cause paralysis and does not affect the cardiovascular and respiratory systems.

Pharmacokinetics. When administered intramuscularly, thiocolchicoside is rapidly distributed in the blood, Cmax in the blood plasma is reached after 15–45 minutes. After one intramuscular injection at a dose of 4 mg of thiocolchicoside, Cmax in blood plasma is 61 ng / ml.

Protein binding (mainly albumin) is 13%. The average apparent volume of distribution is 76 liters after one intramuscular injection at a dose of 4 mg.

T½ is 2.5–5 hours. Approximately 20% of the dose is excreted in the urine as unchanged metabolites, 75–81% is excreted in the feces.

Indications

For additional short-term relief of painful muscle contractures.

Application

Muscomed is used intramuscularly, 2 ml (4 mg) 2 times a day. the recommended period of treatment with the injectable form of the preparation is 3-5 days. if necessary, continue treatment with oral forms of the preparation for 5-7 days in a total daily dose of 16 mg of thiocolchicoside (8 mg 2 times a day).

When preparing for physiotherapy procedures, the period of muscle relaxation is 30–40 minutes after the i / m injection.

Contraindications

Hypersensitivity to the components of the preparation, muscle hypotonia, mild paralysis.

Side effects

Rarely - skin rash, edema, allergic and pseudo-allergic reactions (allergic vasculitis), stomach pain, diarrhea. very rarely - hypotension, irritability and drowsiness.

special instructions

The preparation should be used with caution in case of impaired renal or liver function. the preparation should be used with caution in patients with epilepsy or at risk of seizures.

Application during pregnancy or lactation. The preparation is contraindicated during pregnancy and lactation.

Children. The preparation is contraindicated in children under the age of 16.

The ability to influence the reaction rate when driving or operating other mechanisms. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially unsafe activities that require increased concentration of attention and speed of psychomotor reactions.

Interactions

There are no data on preparation interactions. however, caution is advised when taking concomitantly with other muscle relaxants.

With simultaneous use with preparations that depress the central nervous system, including alcohol, antihypertensive preparations, curariform preparations, it is possible to increase muscle relaxation and inhibition of the central nervous system, the development of hypotension.

With simultaneous use with anticoagulants, the risk of bleeding increases.

Overdose

There is no evidence of overdose.

Symptoms: possible increased adverse reactions.

Treatment: symptomatic, supportive therapy.

Storage conditions

At a temperature not exceeding 25 ° c.

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