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Seizures are also likely. In addition, the simultaneous use of other sympathomimetics together with phenylephrine can lead to an increase in the severity of the vasoconstrictor effect or cardiovascular effect of either of these two medications.

Concomitant use with MAO inhibitors is contraindicated. You should start using this preparation at least 15 days after stopping therapy with MAO inhibitors, since pressor effects may increase (see CONTRAINDICATIONS).

The simultaneous use of phenylephrine with linezolid is not recommended.

Although with local application, side systemic reactions usually do not occur, however, in case of an overdose, an increase in the manifestations of side reactions is possible, especially with prolonged use. cardiac arrhythmias, increased blood pressure, arterial hypotension, pain and discomfort in the region of the heart, palpitations, shortness of breath, noncardiogenic pulmonary edema, agitation, convulsions, headache, tremors, sleep disturbances, anxiety, anxiety, nervousness, irritability, inappropriate behavior may develop , psychosis with hallucinations, insomnia, weakness, anorexia, nausea, vomiting, oliguria, urinary retention, painful or difficult urination, facial flushing, feeling of coldness in the extremities, paresthesias, skin pallor, piloerection, increased sweating, hyperglycemia, vascularity, hypokalemia and vessels of internal organs, a decrease in blood flow to vital organs, which can lead to a deterioration in the blood supply to the kidneys, metabolic acidosis, an increase in the load on the heart due to an increase in the general resistance of peripheral vessels. severe consequences of vasoconstriction can occur more often in patients with hypovolemia and severe bradycardia. there is no specific antidote for phenylephrine poisoning. symptomatic treatment.

At a temperature not higher than 25 ° C.