Nifuroxazid is an intestinal antiseptic, a derivative of 5-nitrofuran; active against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobial agents): gram-positive (staphylococcus family) and gram-negative (enterobacteriaceae family: escherichia, citrobacter, enterobacter, klebsiella, salmonella, shigella, proteus, yersinia), and also vibrio cholerae. not active against bacteria of the genus pseudomonas and genus proteus (species proteus inconstans), as well as strains of subgroup a of the species providentia alcalifaciens.

It is assumed that the preparation inhibits the activity of dehydrogenases and disrupts protein synthesis in pathogenic bacteria. In medium therapeutic doses, it exhibits bacteriostatic activity, and in higher doses, it has a bactericidal effect. The effect is manifested from the first hours of treatment. In therapeutic doses, it practically does not disturb the balance of intestinal microflora; does not lead to the development of resistant strains of pathogenic microorganisms and cross-resistance of bacteria to other antimicrobial agents, which allows, if necessary, for generalized infections to prescribe it in complex therapy with systemic preparations. In case of intestinal infections of viral origin, it prevents the development of bacterial superinfection.

Pharmacokinetics. After taking, it is practically not absorbed from the gastrointestinal tract, creating a high concentration of the active substance in the intestines. Thanks to these pharmacokinetic features, the preparation exhibits an exclusively enteral antiseptic effect, has no systemic antibacterial activity, and does not cause general toxic effects; excreted from the body with feces. The preparation does not affect clinical and biochemical indicators of blood.

Acute diarrhea of infectious etiology.

Hypersensitivity to nifuroxazide, other 5-nitrofuran derivatives or other components of the preparation.

"Nifuroxazid" should be used internally, regardless of food intake, at regular intervals. The suspension must be shaken before use. The maximum daily dose is 800 mg (20 ml).

Children over 2 years of age: 5 ml of suspension 3 times a day.

Adults: 5 ml of suspension 4 times a day.

The duration of treatment is no more than 7 days.

Children. Do not use in children under 2 years of age.

In the treatment of acute diarrhea, substitution therapy should be carried out (orally or parenterally, depending on the patient's condition). should not be limited to the use of only Nifuroxazid in the treatment of diarrhea complicated by sepsis, since the preparation is not absorbed in the intestines and does not enter the bloodstream. during treatment with Nifuroxazide it is contraindicated to drink alcohol (possible development of a disulfiram-like reaction (hyperemia of the skin, feeling of heat, ringing in the ears, difficulty breathing, tachycardia, feeling of fear)). nifuroxazide contains sucrose, which should be taken into account when prescribing the preparation to patients with diabetes. before prescribing the suspension to infants, it is necessary to rule out a deficiency of enzymes that break down sucrose.

There are no data on adverse effects on the fetus when using nifuroxazide during pregnancy, but its use should be avoided if possible. if necessary, under the supervision of a doctor, the preparation can be prescribed to women who are breastfeeding.

Does not affect.

Rarely - abdominal pain, nausea, increased diarrhea. these symptoms do not require discontinuation of treatment. in rare cases, individual hypersensitivity to the preparation is possible (shortness of breath, skin rashes, itching), which requires discontinuation of the preparation and symptomatic therapy.

Cases of overdose have not been described. in case of overdose, gastric lavage and symptomatic treatment are recommended.

Nifuroxazid is not recommended to be used simultaneously with sorbents, as well as with preparations that contain ethanol.

Store in a place protected from light and inaccessible to children, at a temperature not higher than 25 °C. Shelf life - 2 years.