Omez lyophilisate for solution for injection 40 mg, 1 vial — Made in India — Free Delivery

Antiulcer preparation, specific proton pump inhibitor. It inhibits the activity of H + -K + -ATPase in the parietal cells of the stomach, blocking the final stage of the secretion of hydrochloric acid, thereby reducing acid production. Reduces basal and stimulated secretion regardless of the nature of the stimulus.

Omeprazole is a prodrug and is activated in the acidic environment of the secretory tubules of the parietal cells of the stomach.

The antisecretory effect after taking a dose of 20 mg occurs within the first hour, the maximum effect is after 2 hours. Inhibition of 50% of the maximum secretion lasts 24 hours.

A single dose per day provides a quick and effective suppression of daytime and nocturnal gastric secretion, reaching its maximum after 4 days of treatment and disappearing by the end of 3 to 4 days after the end of the intake.

In patients with duodenal ulcer, taking 20 mg of omeprazole maintains the pH in the stomach at 3 for 17 hours.

In severe exacerbation of peptic ulcer disease, reflux esophagitis and NSAID gastropathy, in patients who are not indicated for oral administration of the preparation, the recommended daily dose of Omez® is 40 mg for administration in the form of an preparation infusion.

With Zollinger-Ellison syndrome, the preparation is prescribed at an initial dose of 60 mg / day. The dose should be selected individually, possibly in higher doses (80-120 mg / day). If the daily dose is over 60 mg, it should be divided into 2-3 infusions during the day.

In Mendelssohn's syndrome, the preparation is prescribed at night at a dose of 40 mg and at least 2 hours before anesthesia / surgery at a dose of 40 mg.

In elderly patients, there is no need to adjust the dose.

Rules for the preparation of an infusion solution

The solution for intravenous infusion is prepared immediately before use. To prepare a solution for intravenous infusion, use only 5% dextrose (glucose) solution without preservatives. To dissolve 40 mg of lyophilized omeprazole powder, at least 5 ml of solvent are added to the vial and gently shaken until the lyophilisate is completely dissolved. The prepared solution containing 40 mg of omeprazole is diluted before administration in 100 ml of 5% dextrose (glucose) solution without preservatives for intravenous infusion for at least 30 minutes. Before injection, make sure that there are no suspended particles in the solution. The chemical and physical stability of the prepared omeprazole solution is observed within 6 hours from the moment of dissolution of omeprazole in 5% dextrose (glucose) solution.

The preparation should be prescribed with caution in case of renal and / or hepatic insufficiency.

Application during pregnancy and lactation

The use of the preparation Omez during pregnancy and lactation (breastfeeding) is contraindicated.

Application for violations of liver function

The preparation should be prescribed with caution in liver failure.

Application for impaired renal function

The preparation should be prescribed with caution in case of renal failure.

Application in children

Prescription for children is contraindicated.

Use in elderly patients

In elderly patients, there is no need to adjust the dose.

Before starting therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), because treatment, masking the symptoms, can delay the correct diagnosis.

Influence on the ability to drive vehicles and mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

The preparation should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.

Shelf life of the preparation Omez is 2 years.