Panthestin - Darnitsa gel 30g — Made in Ukraine — Free Delivery

Pharmacological properties

Pharmacodynamic parameters. Pantestin-Darnitsa gel contains two pharmaceutically active ingredients: dexpanthenol and miramistin.

Dexpanthenol, an essential component of a normally functioning epithelium, is a biologically active stable form of pantothenic acid.

Dexpanthenol is easily converted to pantothenic acid, which increases the content of reduced glutathione in cells (antioxidant effect), promotes ATP synthesis, and is also part of coenzyme A (CoA). Molecules CoA and ATP are involved in the synthesis of fatty acids, phospholipids and cholesterol, which are necessary for the repair of cell membranes. In addition, CoA is involved in the reactions of epithelial cell protein metabolism.

In vitro studies have established the effect of dexpanthenol on human fibroblasts - an increase in their proliferation, migration and adhesion processes, collagen synthesis.

Due to its good penetration through the skin and high local concentrations, dexpanthenol is widely used to stimulate epithelialization processes, granulation of damaged skin and reduce itching.

In addition, dexpanthenol improves barrier properties, hydration of the stratum corneum, reduces transepidermal water loss, maintains skin softness and elasticity, and also has anti-inflammatory properties.

In order to prevent infection of long-term healing wounds and treat wound infection, the action of the preparation is supplemented with an antiseptic miramistin.

The surfactant of the cationic type Miramistin, due to the interaction with the lipids of the outer membrane of the microorganism, has a destructive effect on the causative agents of wound infection. Gram-positive cocci are highly sensitive to the substance (primarily staphylococci, as well as streptococci, including pneumococci). Miramistin is also effective against gram-negative pathogens. The activity of Miramistin is aimed at microorganisms of both aerobic and anaerobic types, non-spore-forming and spore-forming; including microbial associations and hospital microflora with multiple antibiotic resistance (increases the sensitivity of microbes to these preparations). Inhibits the formation and growth of biofilms of Staphylococcus aureus and Streptococcus pyogenes (group A). Miramistin also effectively acts on large viruses (including herpes), dermatophytes, ascomycetes, yeast and yeast-like fungi.

Due to the pronounced hyperosmolar effect in the area of ​​the wound and adjacent tissues, the use of Miramistin helps to inhibit the inflammation process.

The local effects of Miramistin are complemented by the stimulation of the restoration of damaged tissues during its use, including in the case of long-term non-healing wounds.

Pharmacokinetic parameters. When applied topically, dexpanthenol is rapidly absorbed, metabolized in tissues to pantothenic acid.

Miramistin is unlikely to enter the systemic circulation, the substance has an effect on microorganisms in the wound area and adjacent tissues.

Indications

Treatment and prevention of infection of minor abrasions, burns, cuts and scratches; skin infections (including secondarily infected neurodermatitis and eczema); wounds of various etiology and location (including postoperative, bedsores and trophic ulcers in the proliferative phase); sunburn; treatment of granulating burn wounds and their preparation for autodermoplasty, improvement of engraftment of skin grafts; periodontal diseases (gingivitis - catarrhal or ulcerative necrotic forms; periodontitis - focal or widespread), diseases or traumatic lesions of the oral mucosa (stomatitis, including aphthous, chronic, recurrent); erosion of the cervix, erosive colpitis and damage to the vaginal mucosa; treatment and prevention of infection of diaper rash and diaper dermatitis; prevention of radiation injuries of the skin, mucous membranes, treatment of radiation ulcers (in the proliferative phase).

Application

Locally. spread in a thin layer on the surface of the wound after its standard treatment. then apply a sterile gauze bandage. as an option, the gel is applied to the dressing material, and then to the wound surface.

If there is a wound exudate, before using the gel, the wound is treated with an antiseptic and dried with a sterile napkin.

In case of damage to the skin and sunburn, the preparation is applied to the affected areas.

Gynecological pathology: tampons soaked in the preparation are inserted in the supine position deep into the vagina.

In the treatment of diseases of the oral cavity, the preparation is used only in adults. After cleansing the oral cavity, the gel is spread in a thin layer over the affected area. For 1 hour, do not consume liquid and food. When treating the manifestations of prosthetic stomatitis, dentures can be used after applying the gel.

Apply 2-3 times a day for 7-10 days (until the affected area is completely healed or the intensity of inflammation decreases).

Contraindications

Hypersensitivity to the active pharmaceutical ingredients of the preparation or its other constituents.

Side effects

Hypersensitivity reactions (as a rule, with individual intolerance, itching, rashes, hyperemia of varying severity are noted); rarely - short-term (disappears spontaneously within 15–20 s) burning sensation; dermatitis (contact or allergic), erythema, eczema, urticaria, irritation, swelling, dryness or weeping of the skin.

Special instructions

Protect eyes from contact with gel.

Do not use in case of severe purulent exudation from the wound.

The duration of treatment is determined by the doctor individually.

During pregnancy and lactation, it is possible to use the gel after consulting a doctor (avoid applying to large areas of the skin).

Used in children from the first days of life.

There is no effect on the reaction rate when driving vehicles or other mechanisms.

Interactions

The antimicrobial effect of Miramistin is inactivated by:

• anionic surfactants (soap solutions);
• other antiseptics.

Combined use of Miramistin:

• with antibiotics (systemic or local) - increases the sensitivity of microorganisms to them;
• with depolarizing muscle relaxants - increases their effectiveness;
• with non-depolarizing muscle relaxants - reduces their effectiveness.

Overdose

When applied topically, it is unlikely. if the gel is accidentally swallowed, symptomatic treatment is performed.

Storage conditions

At a temperature of ≤25 ° C in the original packaging. do not freeze.