Piofag 20ml Solution Pack of 4 | Polyvalent Pyobacteriophage Buy Online

Piofag is a specialized biological preparation containing a polyvalent mixture of sterile filtrates of bacterial phagolysates. This specific 10ml format, provided in a pack of four flacons with dropper caps, is designed for precise dosing and maximum sterility maintenance. Piofag utilizes bacteriophage therapy, a method where naturally occurring viruses specifically target and eliminate pathogenic bacteria. Unlike traditional antibiotics that may affect the entire body, Piofag acts with biological precision, lysing only the harmful pathogens while preserving the patient’s healthy microbiome. This makes it an ideal choice for treating antibiotic-resistant infections and chronic inflammatory conditions in both adults and children.

Composition and Active Substance

Piofag is a clear, liquid solution containing a targeted biological cocktail. Each 20ml flacon contains:

• Active Substances: Sterile purified filtrates of phagolysates of the most common pathogenic bacteria: Staphylococcus, Streptococcus, Proteus (mirabilis and vulgaris), Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli.

• Inactive Ingredients: The solution is maintained in a physiological saline environment and may contain 8-hydroxyquinoline sulfate or Merthiolate as a preservative to ensure the stability of the viral particles.

Pharmacological Action

The efficacy of Piofag is driven by the specific lytic activity of its component bacteriophages. The process occurs in several distinct stages:

1. Selective Attachment: The phage particles recognize specific receptors on the bacterial cell wall and attach exclusively to target pathogens.

2. Viral Injection: The phage injects its DNA into the bacterium.

3. Intracellular Replication: The bacterium is forced to produce hundreds of new phage particles.

4. Bacterial Lysis: The bacterial cell wall ruptures, destroying the pathogen and releasing new phages to continue the process in the surrounding area. Because phages are host-specific, they do not interact with human cells or beneficial bacteria, preventing common antibiotic side effects such as oral or vaginal candidiasis and intestinal dysbiosis.

Indications for Use

Piofag is highly effective for the treatment and prevention of various purulent-inflammatory infections:

• ENT and Respiratory: Sinusitis, otitis media, tonsillitis, pharyngitis, and bacterial bronchitis.

• Dermatology and Surgery: Infected wounds, burns, boils (furuncles), carbuncles, and postoperative wound care.

• Gastroenterology: Dysbiosis of the intestine, enterocolitis, and cholecystitis.

• Urogenital System: Cystitis, urethritis, and pyelonephritis.

• Pediatric Care: Treatment of omphalitis and skin infections in newborns.

Contraindications

• Hypersensitivity: There are no absolute contraindications known for bacteriophage therapy. Users should only exercise caution if they have a known sensitivity to the preservative (8-hydroxyquinoline sulfate).

Dosage and Administration

The 10ml flacons with dropper caps allow for various administration routes:

• Local/Topical: For wounds or skin infections, use the dropper to apply the solution directly or moisten a sterile gauze.

• ENT Usage: For sinusitis or otitis, instill 2-10 drops into the nasal passages or ear canal 1-3 times daily.

• Oral Intake: For gastrointestinal or systemic infections, the solution is taken 1 hour before meals. Adults typically take 20-30 ml (2-3 flacons), while pediatric doses range from 5-15 ml based on age.

• Rectal: Used as a micro-enema (10-20 ml) for intestinal treatments.

Special Administration Tips

The use of 10ml flacons is highly recommended for treatments requiring high sterility, as opening a small bottle reduces the risk of contaminating the entire supply. Before use, ensure the solution is clear and free of sediment. If the liquid appears cloudy, it must be discarded.

Side Effects and Adverse Reactions

Piofag is generally devoid of side effects. In rare instances, a patient might experience a Herxheimer-like reaction—a transient localized redness or mild fever caused by the rapid release of toxins from dying bacteria. This is a physiological response indicating the phages are successfully lysing the infection.

Special Precautions & Warnings

• Sterility Maintenance: When using the dropper, avoid touching the tip to any surface, including the skin or infected wound, to prevent contamination of the remaining liquid.

• Antibiotic Compatibility: Piofag can be used alongside antibiotics. It often works synergistically, helping to clear resistant bacteria that antibiotics may miss.

• Pregnancy and Nursing: This biological product is non-toxic and is considered safe for use by pregnant and breastfeeding women under medical guidance.

Storage Conditions and Shelf Life

• Mandatory Cold Chain: Piofag must be stored in a refrigerator at a temperature between 2°C and 8°C.

• Transportation: Short-term exposure (up to 30 days) to room temperature (up to 25°C) is permissible during transport, but the product must be returned to refrigeration immediately.

• Shelf Life: 2 years. Do not use if the solution shows signs of turbidity (cloudiness).

• Keep out of reach of children.