Posterisan 387.1mg Suppositories | Hemorrhoid Relief & Buy Online

Posterisan 387.1mg suppositories are a specialized proctological treatment designed to combat internal hemorrhoids, anal fissures, and persistent perianal itching. Unlike standard rectal treatments that focus solely on lubrication or temporary numbing, Posterisan utilizes a biological approach. It contains a standardized suspension of bacterial culture (Escherichia coli), which acts as a local immunomodulator. By stimulating the body's natural defense mechanisms directly at the site of inflammation, these suppositories facilitate the regeneration of damaged mucous membranes, reduce swelling, and increase resistance to pathogenic bacteria. This German-engineered preparation is particularly valued for its hormone-free formula, making it suitable for patients who require effective, long-term management of chronic anorectal discomfort.

Composition and Active Substance

Each 2g suppository of Posterisan contains:

• Active Substance: 387.1 mg of a standardized suspension of bacterial culture (CSBC), containing at least 500 million inactivated Escherichia coli bacteria, including their metabolic products and cell wall components.

• Preservative: 6.6 mg of Liquefied Phenol.

• Excipients: Hard fat (adeps solidus) which serves as the base, ensuring even distribution and absorption of the active ingredients.

Pharmacological Action

The therapeutic efficacy of Posterisan 387.1mg is centered on local immunotherapy. When the suppository dissolves in the rectum, the bacterial lysates interact with the mucosal immune system:

1. Immunostimulation: The inactivated E. coli cells act as antigens, triggering the activity of macrophages and T-lymphocytes in the rectal tissue.

2. Antibody Production: It promotes the synthesis of Secretory Immunoglobulin A (sIgA), which strengthens the mucosal barrier against secondary infections and irritants.

3. Anti-inflammatory Effect: By enhancing the local immune response, the medication helps reduce chronic inflammation and venous congestion in the hemorrhoidal plexus.

4. Healing Acceleration: The biological components stimulate fibroblast activity, which is essential for the rapid repair of anal fissures and small mucosal tears.

Indications for Use

• Internal Hemorrhoids: Relief of symptoms such as pressure, bleeding, and discomfort.

• Anal Pruritus: Treatment of persistent itching in the anal and perianal region.

• Anal Fissures: Promoting the closure and healing of internal tears.

• Anal Eczema: Managing skin irritation and inflammation localized within the anal canal.

• Proctitis: Supportive treatment for inflammation of the rectal lining.

Contraindications

• Hypersensitivity: Known allergy to the bacterial lysates, phenol, or the hard fat base.

• Primary Infections: Posterisan should not be used as a standalone treatment for specific local infections (fungal, viral, or specific bacterial infections like tuberculosis) until the primary pathogen is addressed with appropriate antimicrobial therapy.

Dosage and Administration

Posterisan suppositories are intended for rectal administration.

• Standard Dosage: Insert 1 suppository into the rectum twice daily (morning and evening).

• Timing: It is most effective when used after a bowel movement and thorough hygiene of the anal area.

Special Administration Tips

To ensure the medication stays in place and is absorbed correctly, it is recommended to lie on your side for a few minutes after insertion. For chronic conditions, treatment should continue for several days after the symptoms have completely disappeared to ensure tissue stability and prevent immediate recurrence.

Side Effects and Adverse Reactions

Posterisan is generally very well-tolerated. Rare side effects may include:

• Local Irritation: A temporary mild burning or stinging sensation shortly after insertion, often attributed to the phenol preservative.

• Allergic Reactions: Skin rash, redness, or intense itching in individuals hypersensitive to any of the components. If a severe reaction occurs, the treatment should be stopped immediately.

Special Precautions & Warnings

• Pregnancy and Lactation: Because the active ingredients are inactivated bacterial components that act locally, they are not absorbed into the bloodstream in significant amounts. Posterisan is considered safe during pregnancy and breastfeeding, though a doctor’s consultation is always advised.

• Interaction with Other Meds: No known negative interactions with other preparations. However, if using other rectal medications, they should be applied at different times of the day.

• Duration of Use: While the product is hormone-free and safe for extended use, if symptoms do not improve within 7–10 days, a full proctological examination is necessary to rule out other pathologies.

Storage Conditions and Shelf Life

• Store in a cool, dry place at a temperature not exceeding 25°C.

• Keep the suppositories in their original blister packs to protect them from moisture.

• Shelf Life: 3 years. Do not use after the expiry date indicated on the box.

• Keep out of reach of children.