Raenom 5mg 56 tablets — Made in Romania — Free Delivery
(Raenom 5mg )
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Description Raenom 5mg 56 tablets — Made in Romania — Free Delivery
Product description
Raenom tablets are indicated for the symptomatic treatment of chronic stable angina pectoris.
Compound
active ingredient: ivabradine (in the form of ivabradine hydrobromide);
1 coated tablet contains ivabradine 5 mg, which corresponds to 5.863 mg of ivabradine hydrobromide, or;
1 coated tablet contains ivabradine 7.5 mg, which corresponds to 8.795 mg ivabradine hydrobromide;
Excipients: lactose, mannitol (E 421), maltodextrin, croscarmellose sodium, colloidal silicon dioxide (E 551), magnesium stearate;
film coat: polyvinyl alcohol (E 1203), talc (E 553b), titanium dioxide (E 171), polyethylene glycol/PEG 3350 (E 1521), methacrylate copolymer (1:1), iron oxide yellow (E 172), iron oxide red (E172), sodium bicarbonate (E 500).
Contraindications
- Hypersensitivity to the active substance or to any excipients;
- heart rate at rest <70 beats / min before treatment;
- cardiogenic shock;
- acute myocardial infarction;
- severe arterial hypotension (<90/50 mm Hg);
- severe liver failure;
- sick sinus syndrome;
- sinoatrial blockade;
- unstable or acute heart failure;
- dependence on an artificial pacemaker (heart rate is controlled exclusively with the help of an artificial pacemaker);
- unstable angina;
- AV blockade of the III degree.
Mode of application
Tablets are taken orally twice a day (morning and evening) with meals.
Application features
pregnant
Contraindicated.
Children
Contraindicated.
Drivers
Carefully.
Overdose
Overdose can lead to severe and prolonged bradycardia (see section "Adverse reactions"). Severe forms of bradycardia require symptomatic treatment in specialized institutions. In the event of bradycardia with poor haemodynamic tolerance, intravenous β-stimulating agents such as isoprenaline may be considered. If necessary, temporary use of a pacemaker may be considered.
Adverse reactions
The most common adverse reactions of ivabradine - visual phenomena (phosphene) and bradycardia are dose-dependent and due to the pharmacological action of the preparation.
Interaction
Co-administration of ivabradine with strong CYP3A4 inhibitors such as azole antifungals (ketoconazole, itraconazole), macrolide antibiotics (clarithromycin, oral erythromycin, josamycin, telithromycin), HIV protease inhibitors (nelfinavir, ritonavir) and nefazodone is contraindicated ( see section "Contraindications"). Strong inhibitors of CYP3A4, such as ketoconazole (200 mg 1 time per day) and josamycin (1 g twice a day) increase the average plasma concentration of ivabradine by 7-8 times.
Storage conditions
Does not require special storage conditions. Keep out of the reach of children.
Best before date. 3 years.
Tags: Raenom
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