Sotalol Sandoz 160mg 50 tablets — Made in Germany — Free Delivery
(Sotalol Sandoz )
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Description Sotalol Sandoz 160mg 50 tablets — Made in Germany — Free Delivery
Indications
Ventricular arrhythmias:
- prevention of recurrence of life-threatening ventricular tachyarrhythmia;
- Treatment of symptomatic non-sustained ventricular tachyarrhythmias.
Supravetrikulyarny arrhythmias:
- prevention of paroxysmal atrial tachycardia, paroxysmal atrial fibrillation, paroxysmal atrioventricular (AV) nodal reciprocal tachycardia, paroxysmal AV reciprocal tachycardia in the presence of additional pathways, paroxysmal supraventricular tachycardia after surgery;
- maintenance of normal sinus rhythm after conversion of fibrillation or atrial fibrillation.
Contraindications.
- Hypersensitivity to sotalol, sulfonamides or other components of the preparation;
- IV degree heart failure according to the NYHA classification (New York Heart Association) Acute and chronic heart failure II-III degree (in the stage of decompensation)
- acute myocardial infarction
- sick sinus syndrome, including sinoatrial block if the patient does not have a functioning pacemaker; severe dysfunction of the sinus node;
- AV block II-III degree (if the patient does not have a functioning pacemaker);
- congenital or acquired long QT interval syndrome or taking preparations that prolong the QT interval;
- ventricular tachycardia such as torsade de pointes or taking preparations that contribute to the development of this disease;
- symptomatic sinus bradycardia (≤ 45-50 bpm)
- uncontrolled congestive heart failure, including right ventricular heart failure after pulmonary hypertension;
- cardiogenic shock
- anesthesia with preparations that cause myocardial depression
- hypokalemia hypomagnesemia;
- untreated pheochromocytoma;
- arterial hypotension (with the exception of such, resulting from arrhythmias);
- Raynaud's syndrome and severe peripheral circulatory disorders
- bronchial asthma and chronic obstructive pulmonary disease,
- metabolic acidosis,
- renal failure (creatinine clearance <10 ml/min).
Compound
active ingredient: sotalol;
1 tablet contains sotalol hydrochloride 40 mg or 80 mg or 160 mg
excipients: corn starch, lactose, sodium starch (type A), hydroxypropyl cellulose, colloidal silicon dioxide, magnesium stearate.
Method of application and dose.
In the treatment of life-threatening ventricular arrhythmias with antiarrhythmic preparations, it is necessary to start therapy, as well as increase the dose in a hospital setting, with equipment for monitoring and assessing heart rate variability.
During treatment, control studies should be carried out regularly (for example, using a standard ECG - at intervals of 1 month, a long-term ECG - every 3 months, and, if necessary, an ECG during exercise).
Therapy should be reconsidered if individual parameters worsen, for example, an increase in QRS duration or a QT interval of more than 25%, a PQ interval of more than 50%, or an increase in the frequency and severity of arrhythmias.
This dosage regimen is recommended: the initial dose is 80 mg per day as a single dose or in 2 doses (40 mg each) with an interval of 12:00.
If the effectiveness of therapy is insufficient, the daily dose can be gradually increased at intervals of at least 3 days to achieve an equilibrium concentration of sotalol in the blood plasma and control the duration of QT intervals using ECG.
For some patients, a daily dose of 160-320 mg divided into 2 doses may be necessary.
For the prevention of supraventricular arrhythmias, it is recommended to use a dose of 320 mg / day in 2 doses with an interval of 12:00. For the prevention of supraventricular arrhythmia after heart surgery, the daily dose should be 240 mg in 2 divided doses.
Individual patients with persistent life-threatening ventricular arrhythmias may be given 480-640 mg of sotalol per day. However, the appointment of such a dose requires a careful assessment of the ratio of potential benefits and risks of severe adverse reactions (especially proarrhythmic effects).
Tags: Sotalol
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