XALATAN EYE DROPS 0,005% 2,5ML — MADE IN POLAND — FREE SHIPPING
Product description
Xalatan eye
drops - is an ophthalmic preparation for reducing
intraocular pressure in patients with ophthalmotonus and treating open-angle
glaucoma. Improves the outflow of watery moisture, which leads to a decrease in
intraocular pressure, thereby preventing the progression of glaucoma symptoms
(which leads to an irreversible loss of vision - blindness). At the moment is
one of the effective preparation for the treatment of glaucoma.
The antiglaucoma preparation, analogue of
prostaglandin F2α, is a selective agonist of FP receptors (prostaglandin
F) and reduces intraocular pressure (IOP) by increasing the outflow of aqueous
humor mainly by uveoscleral route, and also through the trabecular network.
It has been established that latanoprost does not
significantly affect the production of aqueous humor and the hemato-ophthalmic
barrier.
When used in therapeutic doses, latanoprost does not
have a significant pharmacological effect on the cardiovascular and respiratory
systems.
Decrease in IOP begins approximately 3-4 hours after
the administration of the preparation, the maximum effect is observed after
8-12 hours, the effect is maintained for at least 24 hours.
Pharmacokinetics
Suction
Latanoprost is a preparation , absorbed through the
cornea, where its hydrolysis occurs (under the action of esterases) to form a
biologically active acid. Cmax of latanoprost in aqueous humor is achieved
approximately 2 hours after topical application of the preparation.
Distribution
Vd is 0.16 ± 0.02 l / kg. Latanoprost acid is
determined in aqueous humor during the first 4 hours, and in plasma only within
the first hour after topical application.
Metabolism
Latanoprost acid, entering the systemic circulation,
is metabolized mainly in the liver by beta-oxidation of fatty acids to form
1,2-dinor- and 1,2,3,4-tetranor metabolites.
Excretion
Latanoprost acid is rapidly removed from the plasma:
T1 / 2 is 17 minutes. Systemic clearance is approximately 7 ml / min / kg.
After beta-oxidation in the liver, metabolites are excreted mainly by the
kidneys: after topical application with urine, approximately 88% of the dose is
excreted.
Pharmacokinetics in special clinical cases
Exposure of latanoprost is approximately 2 times
higher in children aged 3 to 12 years than in adult patients and 6 times higher
in children younger than 3 years. However, the safety profile of the preparation is not different in children and adults. The time to reach Cmax of latanoprost
acid in blood plasma is 5 minutes for all age groups. T1 / 2 acid latanoprost
in children is the same as in adults. At equilibrium concentration no
cumulation of latanoprost acid in the blood plasma occurs.
Indications:
Decreased elevated intraocular pressure (IOP) in
adults and children (over 1 year old) with open-angle glaucoma or an elevated
ophthalmotonus.
Contraindications:
- Hypersensitivity to latanoprost or other
components of the preparation.
- Age to 1 year (efficacy and safety not
established).
Carefully:
- Afakia, psevdophakia with a rupture of the
posterior capsule of the lens.
- Patients with risk factors for macular
edema (in the treatment with latanoprost, cases of development of macular
edema, including cystoid edema) are described.
- Inflammatory, neovascular glaucoma (due to
lack of sufficient experience of the preparation).
- Bronchial
asthma.
- Herpetic keratitis in the anamnesis. It is
necessary to avoid the use of Xalatan in patients with active form of
herpetic keratitis and recurrent herpetic keratitis, especially associated
with the use of prostaglandin analogues F 2α.
- In patients with risk factors for
development of iritis / uveitis.
- In patients who are scheduled surgery for
cataracts.
Special instructions:
The preparation Xalatan should not be used more than
once a day, as the more frequent introduction of latanoprost leads to a
weakening of the IOP-lowering effect.
If you miss one dose, the next dose should be
administered at the usual time.
Latanoprost can be used concurrently with other
classes of ophthalmic preparations for topical use in order to reduce IOP. If
the patient simultaneously uses other eye drops, they should be applied at
intervals of at least 5 minutes.
The composition of the preparation Xalatan includes
benzalkonium chloride, which can be absorbed by contact lenses. Before dropping
drops, contact lenses must be removed and reinstalled after 15 minutes.
Latanoprost can cause a gradual increase in the
content of brown pigment in the iris. The change in eye color is due to an
increase in melanin content in the stromal melanocytes of the iris, rather than
an increase in the number of melanocytes themselves. In typical cases, brown
pigmentation appears around the pupil and concentrates on the periphery of the
iris. In this case, the entire iris or parts of it become brown. In most cases,
discoloration is negligible and may not be clinically established. The
enhancement of the pigmentation of the iris of one or both eyes is observed,
mainly, in patients with a mixed color of the iris, which is based on a brown
color. The preparation does not affect the nevi and lentigo iris; The
accumulation of pigment in the trabecular network or in the anterior chamber of
the eye was not noted. In determining the degree of pigmentation of the iris
for more than 5 years, no undesirable effects of pigmentation enhancement have
been detected even with the continuation of latanoprost therapy. In patients,
the degree of IOP decrease was the same regardless of the presence or absence
of enhancement of the pigmentation of the iris. Therefore, treatment with
latanoprost can continue in cases of increased pigmentation of the iris. Such
patients should be under regular supervision and, depending on the clinical
situation, treatment can be discontinued. Increased pigmentation of the iris is
usually observed during the first year after initiation of treatment, rarely -
during the second or third year. After the fourth year of treatment this effect
was not observed. The rate of progression of pigmentation decreases with time
and stabilizes after 5 years. In more distant terms, the effects of increased
iris pigmentation were not studied. After the cessation of treatment of the
enhancement of brown pigmentation, the iris was not noted, however, the
discoloration of the eyes may be irreversible.
In connection with the use of latanoprost, cases of
darkening of the eyelid skin, which can be reversible, are described.
Latanoprost can cause gradual changes in eyelashes and
fleece hair, such as lengthening, thickening, increasing pigmentation,
increasing the density and changing the direction of growth of the eyelashes.
The eyelash changes are reversible and pass after the cessation of treatment.
Patients who apply drops to only one eye may develop
heterochromia.
Impact on the ability to drive vehicles and manage
mechanisms
The use of eye drops can cause a transient blurred
vision. It is necessary to drive with care or use complex equipment during the
use of the preparation.
Suggested Use:
In adults and children older than 1 year: one drop in
the affected eye (a) once a day. The optimal effect is achieved with the use of
the preparation in the evening.
As with any eye drops, in order to reduce the possible
systemic effect of the preparation, immediately after instillation each drop is
recommended to press down the tear point located at the inner corner of the eye
in the lower eyelid. This must be done within 1 minute.
Packaging:
- Comes in original packaging. Item is brand
new and unopened.
Storage:
- Keep away from direct sunlight.
- Keep locked and away from children.
- Store in dry place at room temperature.
- Do not exceed storage temperature higher
than 25 C
Important notice- the outer box design may vary before prior notice!
Tags: XALATAN
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