XANTINOL NICOTINATE 150MG 60 PILLS - MADE IN UKRAINE - FREE SHIPPING
Pharmacological properties
Pharmacodynamics.
Xantinol nicotinate has the effects of theophylline and nicotinic acid: the
mechanism of action is realized due to the blockade of PDE activity,
competition with adenosine for receptors, accumulation of camp, stimulation of
the synthesis of nicotinamide coenzymes and prostanticyclin in the walls of
blood vessels. The preparation expands peripheral blood vessels, improves
collateral and cerebral blood flow, reduces manifestations of cerebral hypoxia,
reduces platelet aggregation, improves microcirculation in the retina, enhances
the contractile function of the heart, improves metabolic processes in the
brain tissue in the postoperative period, reduces the level of cholesterol,
atherogenic lipoproteins, urinary acid, fibrinogen, increases the activity of
lipoprotein lipase, enhances fibrinolysis.
Pharmacokinetics.
Well absorbed in the digestive tract. In the body, the preparation is rapidly
converted first into theophylline and nicotinic acid, then into their
metabolites. It is excreted mainly in the urine as metabolites. When
administered intramuscularly, the effect develops in 5-10 minutes.
Indications
Obliterating
atherosclerosis of the vessels of the lower extremities (intermittent
claudication), Raynaud's disease, diabetic angiopathy, retinopathy,
angioneuropathy, acute thrombophlebitis, acute thrombosis, embolism of blood
vessels, migraine, atherosclerotic disorders of cerebral circulation, poorly
healing tumors, postoperative brain removal trophic ulcers of the lower
extremities, retinal vascular disease, degeneration, retinal detachment.
Application
Pills. Xantinol
nicotinate tablets are prescribed for adults by mouth after meals, without
chewing. reception begins with 1 tablet 3 times a day. if necessary, the dose
is increased to 2-3 tablets 3 times a day. the tablets are swallowed without
chewing. as the condition improves, the dose is reduced to 1 tablet 2-3 times a
day. the course of treatment is usually 2 months. in acute disorders of
cerebral and peripheral circulation, the injectable form of the preparation is
preferable. the maximum daily dose is 1800 mg.
Side effects
Hypersensitivity
reactions: skin rashes (urticaria, erythematous-papular), itching, chills,
fever, burning sensation, tingling sensation, skin hyperemia in the upper body,
especially the neck and head, in isolated cases - angioedema;
from the
central and peripheral nervous system: headache, dizziness; these symptoms
usually disappear after 10–20 minutes and do not require special treatment;
from the
digestive tract: diarrhea, anorexia, gastralgia, nausea, vomiting, increased
activity of hepatic transaminases and alkaline phosphatase;
on the
part of the cardiovascular system: arterial hypotension, moderate tachycardia,
in some cases, it is possible to provoke attacks of angina pectoris, heart
rhythm disturbances, the development of steal syndrome;
from the
respiratory system: in some cases - a feeling of lack of air, shortness of
breath;
on the
part of the endocrine system: with prolonged use in high doses - a decrease in
glucose tolerance;
others:
general weakness, hyperuricemia.
The
occurrence of these symptoms with repeated administration of the preparation is
a contraindication for continuing treatment.
Special instructions
If
necessary, the simultaneous use of cardiac glycosides in order to prevent the
development of bradycardia and arrhythmias, treatment should be carried out
under ECG control.
Caution is prescribed for patients with hypertension or labile blood pressure while using antihypertensive preparation or cardiac glycosides - due to the possible risk of a significant decrease in blood pressure and / or the development of arrhythmias.
As a
result of a possible increase in the level of transaminases and alkaline
phosphatase with prolonged use of xanthinol nicotinate, caution is needed when
it is prescribed to patients with hepatic or renal insufficiency.
It is
prescribed with caution for severe atherosclerosis of coronary and cerebral
vessels, tachysystolic heart rhythm disturbances, as well as for elderly
patients.
With
long-term use of the preparation in high doses, it is possible to change
glucose tolerance, change the biochemical parameters of the blood, which
requires discontinuation of the drug. In patients with diabetes mellitus, it is
necessary to more often determine the level of glucose in the blood. Patients
with an implanted pacemaker are prescribed the preparation in low doses.
The preparation
should not be used with alcohol and coffee.
During
pregnancy and breastfeeding. The preparation is not prescribed during pregnancy
and lactation.
Children.
There is no experience with children.
The
ability to influence the reaction rate when driving and working with other
mechanisms. Care must be taken when driving and operating other mechanisms,
given the possibility of dizziness.
Interactions
In order
to avoid a sharp decrease in blood pressure, the preparation should not be
combined with antihypertensive preparation (blockers of α- and β-adrenoreceptors, sympatholytics, ganglion
blockers, ergot alkaloids). the preparation is incompatible with strophanthin,
MAO inhibitors, alcohol and coffee. when combined with cardiac glycosides, the
risk of developing bradycardia and arrhythmia increases. enhances the
anticoagulant effect of heparin, streptokinase, fibrinolysin.
Incompatibility.
The preparation in the form of a solution is incompatible with strophanthin,
MAO inhibitors. Do not mix with other medicines in the same syringe.
Overdose
The preparation
is low toxic. an acute overdose can manifest itself as arterial hypotension
(weakness, dizziness), tachycardia, abdominal pain, vomiting. symptomatic
treatment.
Storage conditions
In the
original packaging, protected from light at a temperature not exceeding 25 ° C.
Tags: XANTINOL
Buyers Online
- Customer from Särevere, Türi vald logged in
- Customer from Hellerup logged in
- Customer from Verona updated their account details
- Customer from Verona registered for an account
- Customer from Vilanova de bellpuig logged in
- Customer from Vilanova de bellpuig placed a new order for PHOSPHALUGEL ORAL GEL 20 SACHETS — MADE IN FRANCE — FREE SHIPPING
- Customer from Vilanova de bellpuig registered for an account
- Customer from HEL logged in
- Customer from HEL logged in
- Customer from HEL registered for an account
- Customer from Särevere, Türi vald logged in
- Customer placed a new order for 2 x GROPRINOSIN FORTE 1000MG 30 TABS - MADE IN POLAND- FREE SHIPPING
- Customer placed a new order for 2 x NIMESIL 2G X 30 SACHETS 100 MG — MADE IN GERMANY — FREE SHIPPING and 1 more product
- Customer from Huntington added a new address
- Customer from Huntington registered for an account
- Customer from Hellerup logged in
- Customer from Berlin logged in
- Customer from Särevere, Türi vald logged in
- Customer from Haifa logged in
- Customer placed a new order for 2 x BENZACNE 10% GEL 30G — MADE IN JAPAN — FREE SHIPPING