Acic aciclovir (acyclovir) 200mg 25 tablets — Made in Poland by Sandoz — Free Delivery
(Acic 200mg)
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Description Acic aciclovir (acyclovir) 200mg 25 tablets — Made in Poland by Sandoz — Free Delivery
Pharmacological properties
Antiviral agent. active against herpes simplex virus types 1 and 2 (herpes simplex), herpes zoster virus (varicella zoster), Epstein virus - barr, cytomegalovirus.
The antiviral activity of the preparation is highly selective and is due to its competitive interaction with the virus enzyme thymidine kinase. Under the influence of thymidine kinase, the transformation of acyclovir into mono-, di-, and then into acyclovir triphosphate occurs, the latter is incorporated into DNA, which is synthesized for new viruses. Thus, viral DNA is formed, the structure of which contains a defect, leading to inhibition of the replication of new generations of viruses.
After oral administration, acyclovir is partially absorbed in the intestine. Plasma protein binding is 9–33%. The concentration of acyclovir in the CSF is 50% of the concentration of the preparation in the blood plasma.
The only metabolite of the preparation is 9-carboxymethoxymethylguanine. Most of acyclovir is excreted by the kidneys unchanged, 10-15% - as a metabolite. The rate of elimination of the preparation slows down with age, but the half-life does not increase significantly.
With chronic renal failure, the elimination half-life is 19.5 hours; in the case of hemodialysis, the indicator decreases to 5.7 hours, while the concentration in the blood plasma decreases to 60% of the initial value.
Indications
Treatment of infections of the skin and mucous membranes caused by viruses of herpes simplex types 1 and 2, both primary and recurrent, including genital herpes.
Prevention of infections caused by Herpes simplex viruses of the 1st and 2nd types.
Prevention of the development of primary infection and prevention of recurrence of infections caused by Herpes simplex viruses of the 1st and 2nd types in patients with reduced immunity, including recipients with organ or bone marrow transplantation, severe forms of immunodeficiency, including HIV infection.
Infections caused by viruses Varicella zoster (chickenpox and shingles).
Application
For infections caused by the herpes simplex virus, adults and children from 2 years of age are prescribed acycic 200 mg 5 times a day for 5-10 days;
children under 2 years old - 100 mg, 5 times a day (1/2 dose for adults) for 5-10 days.
For the prevention of recurrent genital herpes, the preparation is prescribed at 400 mg 2 times a day or 200 mg 4 times a day; the course of treatment is from 6 months to 1 year.
For the prevention of herpes infection in patients with immunodeficiency or after bone marrow transplantation, Acik is prescribed 400 mg 4 times a day throughout the entire period of risk of infection.
In the treatment of Herpes zoster oftalmicus, the dose of the preparation is 800 mg, 5 times a day for 7-10 days.
Doses of the preparation in the treatment of chickenpox depend on the age of the child (on average 20 mg / kg per dose, but not more than 800 mg) and are:
up to 2 years - 200 mg 4 times a day for 5 days;
from 2 to 6 years - 400 mg 4 times a day for 5 days;
from 6 years old - 800 mg 4 times a day for 5 days.
For patients with chronic renal failure with creatinine clearance less than 10 ml / min, the preparation is prescribed at a dose of 200 mg every 12 hours for the treatment of infections caused by the Herpes simplex virus, and up to 800 mg every 12 hours for the treatment of infections caused by the Herpes zoster virus.
Contraindications
Hypersensitivity to acyclovir.
Side effects
From the gastrointestinal tract: possible nausea, vomiting, diarrhea, intestinal colic, a moderate short-term increase in the levels of bilirubin and transaminases.
From the side of the kidneys: in very rare cases - a slight increase in the concentration of urea and blood creatinine.
Skin: rashes are possible, which quickly disappear after discontinuation of the preparation.
From the side of the central nervous system: in very rare cases, headache, chronic fatigue syndrome, drowsiness or psychomotor agitation, hallucinations, confusion were noted.
Special instructions
Treatment with the preparation should be prescribed as early as possible, if possible - in the prodromal period. the state of the body's immune system is important for the realization of the therapeutic effect. the preparation is more effective in patients with unchanged immunity. in patients with reduced immunity with multiple repeated courses of treatment, the formation of resistance of viruses to acyclovir sometimes occurs.
The use of the preparation during pregnancy is possible only for health reasons. Breastfeeding is discontinued if necessary to use the preparation.
Interactions
With the simultaneous use of the preparation with probenecid, the concentration of acyclovir in the blood plasma increases.
Overdose
In the case of oral administration of more than 5 g of acyclovir, it is recommended to monitor the state of renal function.
In cases of overdose, measures are taken to eliminate the preparation (gastric lavage, the appointment of absorbents), in severe cases - by hemodialysis.
Storage conditions
In a dry, dark place at a temperature not exceeding 25 ° C.
Tags: Аciclovir
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