Metformin-Astrafarm 500 mg Tablets | Indications & Buy Online
US and the Rest of the World: 9 to 20 business days
Description Metformin-Astrafarm 500 mg Tablets | Indications & Buy Online
Metformin-Astrafarm 500 mg is a foundational oral hypoglycemic agent belonging to the biguanide class. It is the primary clinical choice for the treatment of Type 2 Diabetes Mellitus, particularly when dietary adjustments and physical exercise have not sufficiently stabilized blood glucose levels. This medication is especially indicated for patients with excess body weight, as it serves as a first-line preparation to reduce diabetes-related complications. Metformin-Astrafarm can be used as a monotherapy or integrated into complex treatment regimens alongside other oral antidiabetic agents or insulin for both adults and children aged 10 years and older.
Composition and Active Substance
Each film-coated tablet is formulated to provide precise dosing:
Active Substance: Metformin hydrochloride — 500 mg.
Excipients: Povidone, magnesium stearate.
Coating: Hydroxypropylmethylcellulose 2910, 5sPz, PEG 6000, and titanium dioxide.
Pharmacological Action
Metformin-Astrafarm targets high blood sugar through three distinctive biological pathways that do not involve stimulating the pancreas to produce more insulin:
Hepatic Inhibition: It reduces the liver's production of glucose by suppressing gluconeogenesis and glycogenolysis.
Muscle Sensitivity: It enhances the body’s sensitivity to insulin, allowing skeletal muscles to absorb and utilize glucose more efficiently.
Absorption Regulation: It slows the rate of glucose absorption within the gastrointestinal tract.
Because metformin does not increase insulin secretion, it has a very low risk of causing weight gain or hypoglycemia in monotherapy. It also has a beneficial impact on lipid metabolism, helping to lower total cholesterol and LDL levels.
Indications for Use
Primary Treatment for T2DM: For adults and children over 10 years old.
First-line Therapy for Overweight Patients: To minimize macrovascular and microvascular complications.
Combined Protocols: Effective when used in conjunction with other oral hypoglycemic drugs or insulin.
Contraindications
Hypersensitivity to metformin or any tablet components.
Metabolic Disorders: Diabetic ketoacidosis or diabetic precoma.
Renal Impairment: Moderate (Stage IIIb) and severe kidney failure (GFR < 45 ml/min).
Acute Conditions: Severe dehydration, shock, or severe infectious diseases.
Tissue Hypoxia: Decompensated heart failure, respiratory failure, or recent myocardial infarction.
Liver Health: Hepatic failure, acute alcohol poisoning, or alcoholism.
Dosage and Administration
Adults:
Initial Dose: Usually 500 mg or 850 mg taken 2–3 times per day.
Titration: After 10–15 days, adjust the dose based on blood glucose measurements.
Maximum Dose: 3000 mg per day, divided into 3 separate doses.
Method: Always take tablets during or after meals to minimize digestive discomfort.
Children (10+ Years):
Initial Dose: 500 mg or 850 mg once daily.
Maximum Dose: 2000 mg per day, divided into 2–3 doses.
Special Administration Tips
Gradual Increase: A slow increase in dosage is the most effective way to help the digestive system adapt and reduce the incidence of side effects.
Side Effects and Adverse Reactions
Digestive (Very Common): Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These symptoms usually occur at the start of therapy and disappear spontaneously.
Nervous System: Taste disturbances (metallic taste in the mouth).
Metabolic: Rare risk of Lactic Acidosis.
Skin: Isolated reports of itching, redness, or urticaria.
Special Precautions & Warnings
Lactic Acidosis: A rare but life-threatening emergency. Risk increases with kidney dysfunction, alcohol abuse, or dehydration. If severe muscle cramps or weakness occur, seek immediate medical care.
Pregnancy: It is recommended to switch to insulin during pregnancy to maintain the most stable blood glucose levels possible.
Breastfeeding: Use is not recommended as metformin is excreted in breast milk and safety data is limited.
Driving: Monotherapy is safe; however, combined therapy (with insulin or sulfonylureas) requires caution due to potential hypoglycemia.
Storage Conditions and Shelf Life
Store in the original packaging at a temperature not higher than 25°C.
Ensure the medication is kept in a place inaccessible to children.
Shelf Life: 5 years.
Tags: Metformin
Products viewed
2 x INOSITOL 45 CAPS - MADE IN POLAND - FREE SHIPPING
Product descriptionThe Inositol dietary supplement contains vitamin B6, which supports the proper functioning of the nervous system and reduces the feeling of tiredness and weariness.ApplicationSupplementing the diet with active ingredients of the preparation.Recommended intakeAdults 1 capsule 1-2 t..
$25.34
Konegra Deluxe 100 mg 4 tablets — Made in Greece — Free Delivery
Product descriptionKonegra Deluxe tablets are indicated for the treatment of erectile dysfunction, which is defined as the inability to achieve and maintain an erection of the penis necessary for successful intercourse.For the effective action of the preparation Konegra Deluxe, you need sexual arous..
$46.52
Metida 2g x 30 sachets — Made in Israel — Free Delivery
Product descriptionThe dietary supplement Metida is an additional source of natural magnesium with high bioavailability, the raw material for which is extracted from the Dead Sea and vitamin B6 (pyridoxine hydrochloride).Recommendations for useMetis is recommended in order to normalize the func..
$25.34
Essliver Forte 50 capsules — Made in India — Free Delivery
Pharmacological propertiesThe main active ingredient of the preparation is natural phospholipids (substance epl). phospholipids in their chemical structure are similar to endogenous phospholipids, but surpass them due to the high content of polyunsaturated fatty acids. these molecules are incorporat..
$23.03
BODYMAX 50+, 60 TABS - MADE IN NORWEGIA - FREE SHIPPING
Product descriptionThe Bodymax Plus dietary supplement has been developed especially for people over 50 who want to be active, vital and enjoy life. The preparation contains ingredients that reduce fatigue and restore energy. The ingredients of the preparation support physical and mental fitness and..
$20.72
Buyers Online
- Customer from Chartres / France registered for an account
- Customer placed a new order for Augmentin (Amoxicillin) 500mg/125mg 14 tablets — Made in Poland — Free Delivery
- Customer from Armonk registered for an account
- Customer from New York logged in
- Customer placed a new order for GROPRINOSIN 500MG 50 TABS - MADE IN POLAND- FREE SHIPPING
- Customer placed a new order for Zovirax Intensive aciclovir (acyclovir) 50mg/g cream 2g — Made in Poland — Free Delivery
- Customer from Breda registered for an account
- Customer from Schaumburg added a new address
- Customer from Schaumburg updated their address
- Customer from Schaumburg updated their account details
- Customer from Schaumburg registered for an account
- Customer from London registered for an account
- Customer from Miami logged in
- Customer from Mitcham updated their address
- Customer from Mitcham updated their account details
- Customer from Mitcham registered for an account
- Customer from Miami updated their account details
- Customer from Miami placed a new order for Enterosgel pasta 15g x 15 sachets — Made in Ukraine — Free Delivery
- Customer from Miami registered for an account
- Customer placed a new order for RECIGAR 1,5MG 100 TABS — MADE IN POLAND — FREE SHIPPING






